| Gene Symbol | SIRPG |
|---|---|
| Entrez Gene | 55423 |
| Alt Symbol | CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | signal-regulatory protein gamma |
| Other Description | CD172 antigen-like family member B|CD172g antigen|SIRP beta 2|SIRP-beta-2|SIRP-gamma|signal-regulatory protein beta 2|signal-regulatory protein beta-2 |
| Swissprots | Q9NQK8 Q5D051 Q5JV25 B1AKP6 Q9P1W8 Q8WWA5 Q5MKL4 |
| Accessions | EAX10615 EAX10616 EAX10617 EAX10618 Q9P1W8 AA446468 AB042624 BAA95692 AK124224 AK292745 BAF85434 AY748247 AAV88530 AY748248 AAV88531 BC020629 AAH20629 BC064532 AAH64532 DA008008 DB046293 HQ448099 ADQ32580 XM_005260749 XP_005260806 XM_011529286 XP_011527588 XM_011529287 XP_011527589 NM_001039508 NP_001034597 NM_018556 NP_061026 NM_080816 NP_543006 |
| Function | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. {ECO:0000269|PubMed:15383453}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269|PubMed:15383453}. |
| Tissue Specificity | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. {ECO:0000269|PubMed:11185750, ECO:0000269|PubMed:15383453}. |
| Top Pathways | Osteoclast differentiation |
SIRPG - MBS1278248 from MyBioSource
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SIRPG - MBS1270592 from MyBioSource
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Human SIRPG cDNA clone(NM_018556.3) - CDFG001934 from Creative Biomart
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Human SIRPG cDNA clone(NM_080816.2) - CDFG007500 from Creative Biomart
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Human SIRPG cDNA clone(NM_001039508.1) - CDFH017597 from Creative Biomart
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human SIRPG ORF clone - CDCH080386 from Creative Biomart
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human SIRPG ORF clone - CDCH080387 from Creative Biomart
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human SIRPG ORF clone - CDCH080388 from Creative Biomart
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human SIRPG ORF clone - CDCH080389 from Creative Biomart
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human SIRPG ORF clone - CDCH080390 from Creative Biomart
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human SIRPG ORF clone - CDCH080391 from Creative Biomart
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human SIRPG ORF clone - CDCH080392 from Creative Biomart
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human SIRPG ORF clone - CDCH080393 from Creative Biomart
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human SIRPG ORF clone - CDCH080394 from Creative Biomart
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human SIRPG ORF clone - CDCH080395 from Creative Biomart
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Human SIRPG ORF Clone(NM_018556.3) - CDCL175505 from Creative Biomart
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Human SIRPG ORF Clone(NM_001039508.1) - CDCL175506 from Creative Biomart
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Human SIRPG ORF Clone(NM_001039508.1) - CDCL175507 from Creative Biomart
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Human SIRPG ORF Clone(NM_018556.3) - CDCR303901 from Creative Biomart
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Human SIRPG ORF Clone(NM_018556.3) - CDCR303902 from Creative Biomart
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Human SIRPG ORF Clone(NM_018556.3) - CDCR303903 from Creative Biomart
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Human SIRPG ORF Clone(NM_080816.2) - CDCR315282 from Creative Biomart
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Human SIRPG ORF Clone(NM_080816.2) - CDCR315283 from Creative Biomart
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Human SIRPG ORF Clone(NM_001039508.1) - CDCR343681 from Creative Biomart
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Human SIRPG ORF Clone(NM_001039508.1) - CDCR343682 from Creative Biomart
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