| Gene Symbol | SIRPG |
|---|---|
| Entrez Gene | 55423 |
| Alt Symbol | CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | signal-regulatory protein gamma |
| Other Description | CD172 antigen-like family member B|CD172g antigen|SIRP beta 2|SIRP-beta-2|SIRP-gamma|signal-regulatory protein beta 2|signal-regulatory protein beta-2 |
| Swissprots | Q9NQK8 Q5D051 Q5JV25 B1AKP6 Q9P1W8 Q8WWA5 Q5MKL4 |
| Accessions | EAX10615 EAX10616 EAX10617 EAX10618 Q9P1W8 AA446468 AB042624 BAA95692 AK124224 AK292745 BAF85434 AY748247 AAV88530 AY748248 AAV88531 BC020629 AAH20629 BC064532 AAH64532 DA008008 DB046293 HQ448099 ADQ32580 XM_005260749 XP_005260806 XM_011529286 XP_011527588 XM_011529287 XP_011527589 NM_001039508 NP_001034597 NM_018556 NP_061026 NM_080816 NP_543006 |
| Function | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. {ECO:0000269|PubMed:15383453}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269|PubMed:15383453}. |
| Tissue Specificity | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. {ECO:0000269|PubMed:11185750, ECO:0000269|PubMed:15383453}. |
| Top Pathways | Osteoclast differentiation |
SIRP-γ CRISPR/Cas9 KO Plasmid (h) - sc-404902 from Santa Cruz Biotechnology
|
||||||||
SIRP-γ HDR Plasmid (h) - sc-404902-HDR from Santa Cruz Biotechnology
|
||||||||
SIRP-γ Double Nickase Plasmid (h) - sc-404902-NIC from Santa Cruz Biotechnology
|
||||||||
SIRP-γ Double Nickase Plasmid (h2) - sc-404902-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SIRP-γ CRISPR Activation Plasmid (h) - sc-404902-ACT from Santa Cruz Biotechnology
|
||||||||
SIRP-γ CRISPR Activation Plasmid (h2) - sc-404902-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SIRP-γ Lentiviral Activation Particles (h) - sc-404902-LAC from Santa Cruz Biotechnology
|
||||||||
SIRP-γ Lentiviral Activation Particles (h2) - sc-404902-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SIRP-γ siRNA (h) - sc-76499 from Santa Cruz Biotechnology
|
||||||||
SIRP-γ shRNA Plasmid (h) - sc-76499-SH from Santa Cruz Biotechnology
|
||||||||
SIRP-γ shRNA (h) Lentiviral Particles - sc-76499-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19358 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19358 from Sigma-Aldrich
|
||||||||
SIRPG siRNA (Human) - CRJ0699 from Cohesion Biosciences
|
||||||||
SIRPG - MBS8200113 from MyBioSource
|
||||||||
shRNA set against Human SIRPG (NM_001039508.1) - SHH407724 from Creative biogene
|
||||||||
shRNA set against Human SIRPG(NM_080816.2) - SHR226356 from Creative biogene
|
||||||||
shRNA set against Human SIRPG(NM_018556.3) - SHR226410 from Creative biogene
|
||||||||
shRNA set against Human SIRPG(NM_001039508.1) - SHR226446 from Creative biogene
|
||||||||
SIRPG shRNA Plasmid (Human) - CHJ0699 from Cohesion Biosciences
|
||||||||
SIRPG miRNA 3'UTR clone - MiUTR1H-09409 from Creative biogene
|
||||||||
SIRPG miRNA 3'UTR clone - MiUTR1H-09410 from Creative biogene
|
||||||||
SIRPG miRNA 3'UTR clone - MiUTR1H-09411 from Creative biogene
|