TEAD1

Gene Symbol	TEAD1
Entrez Gene	7003
Alt Symbol	AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
Species	Human
Gene Type	protein-coding
Description	TEA domain family member 1 (SV40 transcriptional enhancer factor)
Other Description	protein GT-IIC|transcription factor 13|transcriptional enhancer factor 1|transcriptional enhancer factor TEF-1
Swissprots	E7EV65 P28347 A4FUP2
Accessions	AAB00791 EAW68520 EAW68521 P28347 AB209858 BAD93095 AI189919 AI199443 AK027342 AK075070 AK075176 AK075236 AK310928 AL035973 AL117450 AL133574 AL833289 BC026959 BC115398 AAI15399 BG720371 BU172369 CA420177 CN420966 DR000961 NM_021961 NP_068780
Function	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:000
Subcellular Location	Nucleus.
Tissue Specificity	Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Pan-TEAD (D3F7L) Rabbit mAb - 13295 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D3F7L

TEAD1 Antibody - 8526 from Cell Signaling Technology Prices $239.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

TEAD1 (D9X2L) Rabbit mAb - 12292 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D9X2L

TEF-1 (B-2) - sc-398227 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TEF-1 (E-5) - sc-393976 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TEF-1 (H-4) - sc-376113 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TEF-1 (P-17) - sc-23793 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TEF-1 (H-41) - sc-292514 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TEF-1 (V-25) - sc-134070 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Rabbit Clonality Polyclonal

Anti-TEF1 antibody - ab95029 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TEF1 antibody [403C1a] - ab54404 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 403C1a

Anti-TEF1 antibody [EPR3967(2)] - ab133533 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3967(2)

Anti-TEF1 antibody [EPR3968(2)] - ab133535 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3968(2)

Anti-TEF1 antibody [EPR5278(2)] - ab133304 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5278(2)

Anti-TEF1 antibody [EPR5279] - ab109080 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5279

Anti-TEAD1 Antibody (C-Terminus) IHC-plus™ - LS-B3534 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TEAD1 Antibody - LS-C76315 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-TEAD1 Antibody (N-Terminus) - LS-C30984 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TEAD1 Antibody (clone 403C1a) - LS-C184553 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 403C1a

Anti-TEAD1 Antibody (aa105-150) - LS-C313979 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TEAD1 Antibody (aa195-244) - LS-C109580 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TEAD1 Antibody (Internal, clone EPR5278(2)) - LS-C138954 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5278(2)

Anti-TEAD1 Antibody (Internal, clone EPR3967(2)) IHC-plus™ - LS-B6651 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Monoclonal Clone EPR3967(2)

Anti-TEAD1 Antibody (clone 403C1a) - LS-C342589 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 403C1a

Anti-TEAD1 Antibody (C-Terminus, clone EPR5279) - LS-C138344 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5279

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