| Gene Symbol |
TEAD1
|
| Entrez Gene |
7003
|
| Alt Symbol |
AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TEA domain family member 1 (SV40 transcriptional enhancer factor)
|
| Other Description |
protein GT-IIC|transcription factor 13|transcriptional enhancer factor 1|transcriptional enhancer factor TEF-1
|
| Swissprots |
E7EV65 P28347 A4FUP2
|
| Accessions |
AAB00791 EAW68520 EAW68521 P28347 AB209858 BAD93095 AI189919 AI199443 AK027342 AK075070 AK075176 AK075236 AK310928 AL035973 AL117450 AL133574 AL833289 BC026959 BC115398 AAI15399 BG720371 BU172369 CA420177 CN420966 DR000961 NM_021961 NP_068780
|
| Function |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:000
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
|
| Top Pathways |
Hippo signaling pathway
|