Gene Symbol | TEAD1 |
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Entrez Gene | 7003 |
Alt Symbol | AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1 |
Species | Human |
Gene Type | protein-coding |
Description | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
Other Description | protein GT-IIC|transcription factor 13|transcriptional enhancer factor 1|transcriptional enhancer factor TEF-1 |
Swissprots | E7EV65 P28347 A4FUP2 |
Accessions | AAB00791 EAW68520 EAW68521 P28347 AB209858 BAD93095 AI189919 AI199443 AK027342 AK075070 AK075176 AK075236 AK310928 AL035973 AL117450 AL133574 AL833289 BC026959 BC115398 AAI15399 BG720371 BU172369 CA420177 CN420966 DR000961 NM_021961 NP_068780 |
Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:000 |
Subcellular Location | Nucleus. |
Tissue Specificity | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
Top Pathways | Hippo signaling pathway |
AA (Arachidonic Acid), Human, ELISA Kit - E-EL-H0496 from ARP American Research Products
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Transcriptional enhancer factor TEF-1 (TEAD1), Human, ELISA Kit - CSB-EL023363HU from ARP American Research Products
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AA (Arachidonic Acid), Rabbit, ELISA Kit - E-EL-RB1485 from ARP American Research Products
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AA (Arachidonic Acid), Chicken, ELISA Kit - E-EL-Ch0872 from ARP American Research Products
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AA (Arachidonic Acid), Pig, ELISA Kit - E-EL-P0332 from ARP American Research Products
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AA (Arachidonic Acid), Monkey, ELISA Kit - E-EL-MK0621 from ARP American Research Products
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Arachidonic Acid (AA), Plant, ELISA kit - CSB-EQ027590PL from ARP American Research Products
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Arachidonic acid, AA, General, ELISA Kit - E1098Ge from ARP American Research Products
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Human AA ELISA Kit - HA0697 from NeoScientific
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Anserine AA ELISA Kit - AA0697 from NeoScientific
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Human AA (Arachidonic Acid) CLIA Kit - E-CL-H0402 from Elabscience
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AA, ELISA Kit - MBS2513933 from MyBioSource
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TEA domain family member 1 (SV40 transcriptional enhancer factor) , ELISA Kit - MBS922229 from MyBioSource
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Human Transcriptional enhancer factor TEF-1(TEAD1) ELISA kit - CSB-EL023363HU from Cusabio
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Human Arachidonic Acid ELISA - E01A0690 from BlueGene Biotech
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ELISA Kit for Vitamin C (VC) - CEA913Ge from Cloud-clone
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Human AA (Arachidonic Acid) CLIA Kit - E-CL-H0402 from Iwai North America Inc.
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AA (Arachidonic Acid), CLIA Kit - MBS2531690 from MyBioSource
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AA(Arachidonic Acid) ELISA Kit - E-EL-0051 from Elabscience
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Human AA ELISA Kit - orb339631 from Biorbyt
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Human Transcriptional enhancer factor TEF-1 (TEAD1) ELISA Kit - EKC35839 from Biomatik
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AA - EKU5138 from Nordic BioSite
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Human AA ELISA Kit - E003545 from Biobool
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Human TEAD1 ELISA Kit - E037633 from Biobool
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Human AA ELISA Kit - EHA0697 from ABclonal
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