| Gene Symbol | TEAD1 |
|---|---|
| Entrez Gene | 7003 |
| Alt Symbol | AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
| Other Description | protein GT-IIC|transcription factor 13|transcriptional enhancer factor 1|transcriptional enhancer factor TEF-1 |
| Swissprots | E7EV65 P28347 A4FUP2 |
| Accessions | AAB00791 EAW68520 EAW68521 P28347 AB209858 BAD93095 AI189919 AI199443 AK027342 AK075070 AK075176 AK075236 AK310928 AL035973 AL117450 AL133574 AL833289 BC026959 BC115398 AAI15399 BG720371 BU172369 CA420177 CN420966 DR000961 NM_021961 NP_068780 |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:000 |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| Top Pathways | Hippo signaling pathway |
TEF-1 CRISPR/Cas9 KO Plasmid (h) - sc-402607 from Santa Cruz Biotechnology
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TEF-1 HDR Plasmid (h) - sc-402607-HDR from Santa Cruz Biotechnology
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TEF-1 Double Nickase Plasmid (h) - sc-402607-NIC from Santa Cruz Biotechnology
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TEF-1 Double Nickase Plasmid (h2) - sc-402607-NIC-2 from Santa Cruz Biotechnology
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TEF-1 CRISPR Activation Plasmid (h) - sc-402607-ACT from Santa Cruz Biotechnology
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TEF-1 CRISPR Activation Plasmid (h2) - sc-402607-ACT-2 from Santa Cruz Biotechnology
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TEF-1 Lentiviral Activation Particles (h) - sc-402607-LAC from Santa Cruz Biotechnology
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TEF-1 Lentiviral Activation Particles (h2) - sc-402607-LAC-2 from Santa Cruz Biotechnology
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TEF-1 siRNA (h) - sc-106608 from Santa Cruz Biotechnology
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TEF-1 shRNA Plasmid (h) - sc-106608-SH from Santa Cruz Biotechnology
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TEF-1 shRNA (h) Lentiviral Particles - sc-106608-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21195 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21195 from Sigma-Aldrich
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TEAD1 siRNA (Human) - CRH4780 from Cohesion Biosciences
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TEF1 RNAi - H00007003-R01 from Novus Biologicals
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TEAD1 - MBS8227383 from MyBioSource
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shRNA set against Human TEAD1 (NM_021961.5) - SHH425424 from Creative biogene
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Human TEAD1 siRNA - orb265282 from Biorbyt
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TEAD1 shRNA Plasmid (Human) - CHH4780 from Cohesion Biosciences
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