Gene Symbol | DRAP1 |
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Entrez Gene | 10589 |
Alt Symbol | NC2-alpha |
Species | Human |
Gene Type | protein-coding |
Description | DR1-associated protein 1 (negative cofactor 2 alpha) |
Other Description | dr1-associated corepressor|negative co-factor 2-alpha|negative cofactor 2 alpha|negative cofactor 2-alpha |
Swissprots | Q14919 Q13448 |
Accessions | EAW74472 Q14919 BC010025 AAH10025 BG036132 BG719065 BQ773919 EU446936 ABZ92465 X96506 CAA65358 NM_006442 NP_006433 |
Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
NC2α (H-3) - sc-374336 from Santa Cruz Biotechnology
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NC2α (V-18) - sc-17272 from Santa Cruz Biotechnology
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Anti-NC2 alpha antibody [EPR15426(B)] - ab183726 from Abcam
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Anti-DRAP1 Antibody - LS-C14946 from LifeSpan Bioscience
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Anti-DRAP1 Antibody - LS-C14947 from LifeSpan Bioscience
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Anti-DRAP1 Antibody - LS-C210800 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (FITC) - LS-C210802 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (HRP) - LS-C210801 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (Biotin) - LS-C210803 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29, AP) - LS-C222231 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29, APC) - LS-C222232 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29, Biotin) - LS-C222233 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29, Azide-free, HRP) - LS-C222236 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29, PE) - LS-C222238 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29, FITC) - LS-C222234 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-30) - LS-C320950 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (N-Terminus) - LS-C107609 from LifeSpan Bioscience
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Anti-DRAP1 Antibody (aa1-29) - LS-C159488 from LifeSpan Bioscience
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DRAP1 Antibody - NBP1-81008 from Novus Biologicals
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DRAP1 Antibody - H00010589-A01 from Novus Biologicals
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DR1 protein Polyclonal Antibody - bs-9055R from Bioss
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Anti-DRAP1 antibody produced in rabbit - HPA006790 from Sigma-Aldrich
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Anti-DRAP1, (N-terminal) antibody produced in rabbit - SAB2104800 from Sigma-Aldrich
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DRAP1 antibody - N-terminal region (ARP31488_P050) - ARP31488_P050 from Aviva Systems Biology
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DRAP1-Antibody-N-term - AP18211a from Abgent, a WuXi AppTec company
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