Gene Symbol | DRAP1 |
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Entrez Gene | 10589 |
Alt Symbol | NC2-alpha |
Species | Human |
Gene Type | protein-coding |
Description | DR1-associated protein 1 (negative cofactor 2 alpha) |
Other Description | dr1-associated corepressor|negative co-factor 2-alpha|negative cofactor 2 alpha|negative cofactor 2-alpha |
Swissprots | Q14919 Q13448 |
Accessions | EAW74472 Q14919 BC010025 AAH10025 BG036132 BG719065 BQ773919 EU446936 ABZ92465 X96506 CAA65358 NM_006442 NP_006433 |
Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
NC2α CRISPR/Cas9 KO Plasmid (h) - sc-408691 from Santa Cruz Biotechnology
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NC2α HDR Plasmid (h) - sc-408691-HDR from Santa Cruz Biotechnology
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NC2α Double Nickase Plasmid (h) - sc-408691-NIC from Santa Cruz Biotechnology
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NC2α Double Nickase Plasmid (h2) - sc-408691-NIC-2 from Santa Cruz Biotechnology
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NC2α CRISPR Activation Plasmid (h) - sc-408691-ACT from Santa Cruz Biotechnology
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NC2α CRISPR Activation Plasmid (h2) - sc-408691-ACT-2 from Santa Cruz Biotechnology
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NC2α Lentiviral Activation Particles (h) - sc-408691-LAC from Santa Cruz Biotechnology
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NC2α Lentiviral Activation Particles (h2) - sc-408691-LAC-2 from Santa Cruz Biotechnology
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NC2α siRNA (h) - sc-38091 from Santa Cruz Biotechnology
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NC2α shRNA Plasmid (h) - sc-38091-SH from Santa Cruz Biotechnology
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NC2α shRNA (h) Lentiviral Particles - sc-38091-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU153451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7488 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7488 from Sigma-Aldrich
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DRAP1 siRNA (Human) - CRH7207 from Cohesion Biosciences
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DRAP1 RNAi - H00010589-R01 from Novus Biologicals
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DRAP1 - MBS8231468 from MyBioSource
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shRNA set against Human DRAP1 (NM_006442.3) - SHH280989 from Creative biogene
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Human DRAP1 siRNA - orb267709 from Biorbyt
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DRAP1 shRNA Plasmid (Human) - CHH7207 from Cohesion Biosciences
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DRAP1 miRNA 3'UTR clone - MiUTR3H-04846 from Creative biogene
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