Gene Symbol |
DRAP1
|
Entrez Gene |
10589
|
Alt Symbol |
NC2-alpha
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
DR1-associated protein 1 (negative cofactor 2 alpha)
|
Other Description |
dr1-associated corepressor|negative co-factor 2-alpha|negative cofactor 2 alpha|negative cofactor 2-alpha
|
Swissprots |
Q14919 Q13448
|
Accessions |
EAW74472 Q14919 BC010025 AAH10025 BG036132 BG719065 BQ773919 EU446936 ABZ92465 X96506 CAA65358 NM_006442 NP_006433
|
Function |
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}.
|
Subcellular Location |
Nucleus {ECO:0000305}.
|
Tissue Specificity |
Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}.
|