| Gene Symbol | DRAP1 |
|---|---|
| Entrez Gene | 10589 |
| Alt Symbol | NC2-alpha |
| Species | Human |
| Gene Type | protein-coding |
| Description | DR1-associated protein 1 (negative cofactor 2 alpha) |
| Other Description | dr1-associated corepressor|negative co-factor 2-alpha|negative cofactor 2 alpha|negative cofactor 2-alpha |
| Swissprots | Q14919 Q13448 |
| Accessions | EAW74472 Q14919 BC010025 AAH10025 BG036132 BG719065 BQ773919 EU446936 ABZ92465 X96506 CAA65358 NM_006442 NP_006433 |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
DR1-associated protein 1 (negative cofactor 2 alpha) , ELISA Kit - MBS9329323 from MyBioSource
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Human DRAP1 ELISA Kit - E012395 from Biobool
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Dr1-associated corepressor, ELISA Kit - MBS285728 from MyBioSource
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Dr1-associated corepressor, ELISA Kit - MBS284187 from MyBioSource
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