Gene Symbol | DRAP1 |
---|---|
Entrez Gene | 10589 |
Alt Symbol | NC2-alpha |
Species | Human |
Gene Type | protein-coding |
Description | DR1-associated protein 1 (negative cofactor 2 alpha) |
Other Description | dr1-associated corepressor|negative co-factor 2-alpha|negative cofactor 2 alpha|negative cofactor 2-alpha |
Swissprots | Q14919 Q13448 |
Accessions | EAW74472 Q14919 BC010025 AAH10025 BG036132 BG719065 BQ773919 EU446936 ABZ92465 X96506 CAA65358 NM_006442 NP_006433 |
Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |