| Gene Symbol |
SLC11A1
|
| Entrez Gene |
6556
|
| Alt Symbol |
LSH, NRAMP, NRAMP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
|
| Other Description |
NRAMP 1|natural resistance-associated macrophage protein 1|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1|solute carrier family 11 (sodium/phosphate symporters), member 1|solute carrier family 11 member 1
|
| Swissprots |
P49279 C0H5Y3
|
| Accessions |
AAA57556 AAA57557 AAG15403 AAG15405 AAQ21581 BAA09782 CAA57541 CAD39201 EAW70611 EAW70612 EAW70613 EAW70614 P49279 AB209650 BAD92887 AK294707 BAG57862 AK298667 BAG60835 AK303398 BAG64454 AK307954 AK310914 AK311405 BC033754 BC037550 BC041787 BC071165 AAH71165 CA307182 D38171 BAA07370 D50402 BAA08907 D50403 BAA08908 DB284801 L32185 AAA57521 XM_005246793 XP_005246850 XM_005246794 XP_005246851 XM_006712709 XP_006712772 XM_006712710 XP_006712773 XM_006712711 XP_006712774 XM_011511684 XP_011509986 XM_011511685 XP_011509987 XR_427107 XR_427108 NM_000578 NP_000569 NM_001032220
|
| Function |
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Macrophages; peripheral blood leukocytes, lung, spleen and liver.
|
| Top Pathways |
Lysosome, Mineral absorption
|