SLC11A1

Gene Symbol	SLC11A1
Entrez Gene	6556
Alt Symbol	LSH, NRAMP, NRAMP1
Species	Human
Gene Type	protein-coding
Description	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Other Description	NRAMP 1|natural resistance-associated macrophage protein 1|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1|solute carrier family 11 (sodium/phosphate symporters), member 1|solute carrier family 11 member 1
Swissprots	P49279 C0H5Y3
Accessions	AAA57556 AAA57557 AAG15403 AAG15405 AAQ21581 BAA09782 CAA57541 CAD39201 EAW70611 EAW70612 EAW70613 EAW70614 P49279 AB209650 BAD92887 AK294707 BAG57862 AK298667 BAG60835 AK303398 BAG64454 AK307954 AK310914 AK311405 BC033754 BC037550 BC041787 BC071165 AAH71165 CA307182 D38171 BAA07370 D50402 BAA08907 D50403 BAA08908 DB284801 L32185 AAA57521 XM_005246793 XP_005246850 XM_005246794 XP_005246851 XM_006712709 XP_006712772 XM_006712710 XP_006712773 XM_006712711 XP_006712774 XM_011511684 XP_011509986 XM_011511685 XP_011509987 XR_427107 XR_427108 NM_000578 NP_000569 NM_001032220
Function	Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Macrophages; peripheral blood leukocytes, lung, spleen and liver.
Top Pathways	Lysosome, Mineral absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NRAMP1 full length protein - ab159530 from Abcam Category Protein Source Wheat germ Species Human

Human NRAMP1 protein fragment - ab159531 from Abcam Category Protein Source Wheat germ Species Human

SLC11A1 / NRAMP Antibody Blocking Peptide - LS-E9612 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NRAMP1/SLC11A1 Protein - H00006556-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NRAMP1/SLC11A1 Protein - H00006556-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SLC11A1-Antibody-Center-Blocking-Peptide - BP8514c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SLC11A1 Blocking Peptide - 33R-9676 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NRAMP1 - H00006556-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NRAMP1 - H00006556-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NRAMP1 - H00006556-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NRAMP1 - H00006556-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SLC11A1 fusion protein - ag12294 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NRAMP1/SLC11A1 Recombinant Protein Antigen - NBP1-87809PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SLC11A1 Peptide, Human - M34GP14312H from Creative Peptides Category Peptide Source Synthetic. Species Human

Natural resistance-associated macrophage protein 1 (SLC11A1), Recombinant Protein - MBS966197 from MyBioSource Category Protein Prices $820.00, $820.00, $1,045.00, $1,045.00, $1,110.00, $1,110.00, $1,570.00, $1,570.00, $1,605.00, $2,200.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SLC11A1 fusion protein - Ag24758 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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