SLC11A1
| Gene Symbol | SLC11A1 |
|---|---|
| Entrez Gene | 6556 |
| Alt Symbol | LSH, NRAMP, NRAMP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 |
| Other Description | NRAMP 1|natural resistance-associated macrophage protein 1|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1|solute carrier family 11 (sodium/phosphate symporters), member 1|solute carrier family 11 member 1 |
| Swissprots | P49279 C0H5Y3 |
| Accessions | AAA57556 AAA57557 AAG15403 AAG15405 AAQ21581 BAA09782 CAA57541 CAD39201 EAW70611 EAW70612 EAW70613 EAW70614 P49279 AB209650 BAD92887 AK294707 BAG57862 AK298667 BAG60835 AK303398 BAG64454 AK307954 AK310914 AK311405 BC033754 BC037550 BC041787 BC071165 AAH71165 CA307182 D38171 BAA07370 D50402 BAA08907 D50403 BAA08908 DB284801 L32185 AAA57521 XM_005246793 XP_005246850 XM_005246794 XP_005246851 XM_006712709 XP_006712772 XM_006712710 XP_006712773 XM_006712711 XP_006712774 XM_011511684 XP_011509986 XM_011511685 XP_011509987 XR_427107 XR_427108 NM_000578 NP_000569 NM_001032220 |
| Function | Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Macrophages; peripheral blood leukocytes, lung, spleen and liver. |
| Top Pathways | Lysosome, Mineral absorption |
NRAMP 1 CRISPR/Cas9 KO Plasmid (h) - sc-402423 from Santa Cruz Biotechnology
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NRAMP 1 HDR Plasmid (h) - sc-402423-HDR from Santa Cruz Biotechnology
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NRAMP 1 Double Nickase Plasmid (h) - sc-402423-NIC from Santa Cruz Biotechnology
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NRAMP 1 Double Nickase Plasmid (h2) - sc-402423-NIC-2 from Santa Cruz Biotechnology
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NRAMP 1 CRISPR Activation Plasmid (h) - sc-402423-ACT from Santa Cruz Biotechnology
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NRAMP 1 CRISPR Activation Plasmid (h2) - sc-402423-ACT-2 from Santa Cruz Biotechnology
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NRAMP 1 Lentiviral Activation Particles (h) - sc-402423-LAC from Santa Cruz Biotechnology
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NRAMP 1 Lentiviral Activation Particles (h2) - sc-402423-LAC-2 from Santa Cruz Biotechnology
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NRAMP 1 siRNA (h) - sc-36099 from Santa Cruz Biotechnology
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NRAMP 1 shRNA Plasmid (h) - sc-36099-SH from Santa Cruz Biotechnology
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NRAMP 1 shRNA (h) Lentiviral Particles - sc-36099-V from Santa Cruz Biotechnology
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NRAMP1/SLC11A1 RNAi - H00006556-R02 from Novus Biologicals
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MISSION® esiRNA - EHU091701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19401 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10405 from Sigma-Aldrich
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SLC11A1 siRNA (Human) - CRH4446 from Cohesion Biosciences
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NRAMP1/SLC11A1 RNAi - H00006556-R01 from Novus Biologicals
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SLC11A1 - MBS8206993 from MyBioSource
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shRNA set against Human SLC11A1 (NM_000578.3) - SHH408276 from Creative biogene
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shRNA set against Human SLC11A1(NM_000578.3) - SHR228261 from Creative biogene
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Human SLC11A1 siRNA - orb264948 from Biorbyt
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SLC11A1 shRNA Plasmid (Human) - CHH4446 from Cohesion Biosciences
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SLC11A1 miRNA 3'UTR clone - MiUTR1H-09430 from Creative biogene
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