SLC11A1

Gene Symbol SLC11A1
Entrez Gene 6556
Alt Symbol LSH, NRAMP, NRAMP1
Species Human
Gene Type protein-coding
Description solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Other Description NRAMP 1|natural resistance-associated macrophage protein 1|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1|solute carrier family 11 (sodium/phosphate symporters), member 1|solute carrier family 11 member 1
Swissprots P49279 C0H5Y3
Accessions AAA57556 AAA57557 AAG15403 AAG15405 AAQ21581 BAA09782 CAA57541 CAD39201 EAW70611 EAW70612 EAW70613 EAW70614 P49279 AB209650 BAD92887 AK294707 BAG57862 AK298667 BAG60835 AK303398 BAG64454 AK307954 AK310914 AK311405 BC033754 BC037550 BC041787 BC071165 AAH71165 CA307182 D38171 BAA07370 D50402 BAA08907 D50403 BAA08908 DB284801 L32185 AAA57521 XM_005246793 XP_005246850 XM_005246794 XP_005246851 XM_006712709 XP_006712772 XM_006712710 XP_006712773 XM_006712711 XP_006712774 XM_011511684 XP_011509986 XM_011511685 XP_011509987 XR_427107 XR_427108 NM_000578 NP_000569 NM_001032220
Function Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Macrophages; peripheral blood leukocytes, lung, spleen and liver.
Top Pathways Lysosome, Mineral absorption

NRAMP 1 (E-20) - sc-16885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NRAMP 1 (E-20): sc-16885. Western blot analysis of NRAMP 1 expression in NAMALWA whole cell lysate.

NRAMP 1 (H-100) - sc-20113 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NRAMP 1 (H-100): sc-20113. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in glomeruli and tubuli at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

NRAMP 1 (N-20) - sc-16884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NRAMP 1 (N-20): sc-16884. Western blot analysis of NRAMP 1 expression in U-937 whole cell lysate.

Anti-NRAMP1 antibody - ab59696 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NRAMP1 antibody (ab59696) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-NRAMP1 antibody - ab58138 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HepG2 cells stained with ab58138 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab58138, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was an anti-mouse Alexa Fluor® 488 (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-NRAMP1 antibody - ab175986 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NRAMP1 antibody (ab175986) at 1/1000 dilution + CEM cell line lysates at 35 µg

Anti-NRAMP1 antibody - ab172210 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NRAMP1 antibody (ab172210) at 1 µg/mlLane 1 : NRAMP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-SLC11A1 / NRAMP Antibody (C-Terminus) - LS-C16690 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Extracellular Domain) - LS-C16692 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Extracellular Domain) - LS-C16693 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal, AP) - LS-C282879 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal, APC) - LS-C282880 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal, Biotin) - LS-C282882 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal, Azide-free, HRP) - LS-C282884 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal, FITC) - LS-C282883 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal, PE) - LS-C282885 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (Internal) - LS-C330664 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC11A1 / NRAMP Antibody (aa401-450) - LS-C40419 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-SLC11A1 / NRAMP Antibody (aa211-260) - LS-C205735 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC11A1 / NRAMP antibody Western Blot of HT1080. Antibody dilution: 1 ug/ml.

Anti-SLC11A1 / NRAMP Antibody (clone 2G2) - LS-C198214 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G2
SLC11A1 monoclonal antibody (M01), clone 2G2. Western Blot analysis of SLC11A1 expression in human liver.

Anti-SLC11A1 / NRAMP Antibody (aa250-276) IHC-plus™ - LS-B9344 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC11A1 / NRAMP antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-SLC11A1 / NRAMP Antibody - LS-C179225 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

NRAMP1/SLC11A1 Antibody - NBP1-59785 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NRAMP1/SLC11A1 Antibody - NBP2-29924 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NRAMP1/SLC11A1 Antibody [NBP2-29924] - Analysis of SLC11A1 Antibody in CEM cell line lysates (35ug/lane). SLC11A1was detected using the purified Pab.

NRAMP1/SLC11A1 Antibody (2G2) - H00006556-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G2
Western Blot: NRAMP1/SLC11A1 Antibody (2G2) [H00006556-M01] - SLC11A1 monoclonal antibody (M01), clone 2G2. Analysis of SLC11A1 expression in human liver.
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