PDCD4

Gene Symbol	PDCD4
Entrez Gene	27250
Alt Symbol	H731
Species	Human
Gene Type	protein-coding
Description	programmed cell death 4 (neoplastic transformation inhibitor)
Other Description	neoplastic transformation inhibitor protein\|nuclear antigen H731\|programmed cell death protein 4\|protein 197/15a
Swissprots	B2RCV4 Q6PJI5 B5ME91 Q5VZS6 O15501 Q8TAR5 Q99834 Q53EL6
Accessions	AAB42218 EAW49552 EAW49553 EAW49554 Q53EL6 AK223623 BAD97343 AK296753 BAG59336 AK312540 BAG35439 AK315295 BAG37701 AL049932 BC015036 AAH15036 BC026104 AAH26104 BC031049 AAH31049 BI910668 BX537500 BX641168 BX647834 DB241608 DQ891645 ABM82571 DQ894834 ABM85760 U96628 AAB67706 NM_001199492 NP_001186421 NM_014456 NP_055271 NM_145341 NP_663314
Function	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
Tissue Specificity	Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269\|PubMed:10632927, ECO:0000269\|PubMed:12898601, ECO:0000269\|PubMed:16449643}.
Top Pathways	MicroRNAs in cancer, Proteoglycans in cancer

PDCD4 (D29C6) XP ® Rabbit mAb - 9535 from Cell Signaling Technology

Prices	$109.00, $277.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D29C6

Western blot analysis of extracts from various cell types using PDCD4 (D29C6) XP ® Rabbit mAb.

Pdcd-4 (B-4) - sc-376430 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Pdcd-4 (B-4): sc-376430. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing nuclear and cytoplasmic staining of glandular cells.

Pdcd-4 (C-16) - sc-27123 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Pdcd-4 (C-16): sc-27123. Western blot analysis of Pdcd-4 expression in SK-BR-3 nuclear extract.

Pdcd-4 (G-15) - sc-27122 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Pdcd-4 (H-171) - sc-292504 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Pdcd-4 (k4C1) - sc-130545 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

Pdcd-4 (k4C1): sc-130545. Western blot analysis of Pdcd-4 expression in Hep G2 whole cell lysate.

Anti-PDCD4 (phospho S457) antibody - ab74141 from Abcam

Prices	$379.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Paraffin embedded human breast carcinoma tissue stained with ab74141 at a 1/50 dilution. 1: No phosphopeptide 2: Phosphopeptide present

Anti-PDCD4 (phospho S457) antibody - ab195824 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PDCD4 (phospho S457) antibody (ab195824) at 1/500 dilutionLane 1 : serum treated 293 whole cell lysates with antigen-specific peptideLane 2 : serum treated 293 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-PDCD4 (phospho S457) antibody [9G6] - ab105998 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	9G6

All lanes : Anti-PDCD4 (phospho S457) antibody [9G6] (ab105998) at 1/2000 dilutionLane 1 : NIH-3T3 cells stimulated with 30 ng/ml PDGF (5 min treatment)Lane 2 : Unstimulated (non-phosphorylated) NIH 3T3 cellsSecondaryHRP conjugated Rabbit anti-Mouse IgG at 1/2000 dilution

Anti-PDCD4 (phospho S67) antibody - ab73343 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PDCD4 (phospho S67) antibody (ab73343) at 1/500 dilutionLane 1 : HepG2 cell extractLane 2 : HepG2 cell extract with immunising phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-PDCD4 (phospho S67) antibody - ab195815 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PDCD4 (phospho S67) antibody (ab195815) at 1/500 dilutionLane 1 : HepG2 whole cell lysate with antigen-specific peptideLane 2 : HepG2 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-PDCD4 (phospho S67) antibody - ab194522 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PDCD4 (phospho S67) antibody (ab194522) at 1/500 dilutionLane 1 : HepG2 cell lysate with without the antigen specific peptideLane 2 : HepG2 cell lysate with with the antigen specific peptide

Anti-PDCD4 antibody - ab51495 from Abcam

Prices	$400.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PDCD4 antibody (ab51495) at 1/5000 dilutionLane 1 : recombinant PDCD4Lane 2 : 293 HEK cells treated with TPA and MG132.

Anti-PDCD4 antibody - ab63359 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PDCD4 antibody (ab63359) at 1/500 dilutionLane 1 : extracts from 293 cellsLane 2 : extracts from 293 cells, with immunizing peptide

Anti-PDCD4 antibody - ab89940 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-PDCD4 antibody (ab89940) at 1 µg/ml + human pancreas lysate at 50 µgdeveloped using the ECL technique

Anti-PDCD4 antibody - ab116552 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PDCD4 antibody (ab116552) at 1/100 dilution + HL60 cell lysate at 35 µg

Anti-PDCD4 antibody [EPR3431] - ab80590 from Abcam

Prices	$387.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3431

All lanes : Anti-PDCD4 antibody [EPR3431] (ab80590) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : HL60 + RA lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-PDCD4 antibody [EPR3432] - ab79405 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3432

All lanes : Anti-PDCD4 antibody [EPR3432] (ab79405) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-PDCD4 antibody [k4C1] - ab71507 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	k4C1

Anti-PDCD4 antibody [k4C1] (ab71507) at 1/2000 dilution + HepG2 cell lysate at 40 µgSecondaryGoat anti-mouse secondary conjugated to HRPdeveloped using the ECL technique

Anti-PDCD4 Antibody (aa1-469) - LS-C74212 from LifeSpan Bioscience

Prices	$355.00
Sizes	50 µl
Host	Mouse
Clonality	Monoclonal

Anti-PDCD4 Antibody (aa100-150) - LS-C93127 from LifeSpan Bioscience

Prices	$545.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PDCD4 Antibody (aa419-469) - LS-C93128 from LifeSpan Bioscience

Prices	$545.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PDCD4 Antibody (N-Terminus) - LS-C29959 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PDCD4 Antibody (C-Terminus) - LS-C122296 from LifeSpan Bioscience

Prices	$445.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PDCD4 Antibody (N-Terminus) - LS-C31656 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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