| Gene Symbol | PDCD4 |
|---|---|
| Entrez Gene | 27250 |
| Alt Symbol | H731 |
| Species | Human |
| Gene Type | protein-coding |
| Description | programmed cell death 4 (neoplastic transformation inhibitor) |
| Other Description | neoplastic transformation inhibitor protein|nuclear antigen H731|programmed cell death protein 4|protein 197/15a |
| Swissprots | B2RCV4 Q6PJI5 B5ME91 Q5VZS6 O15501 Q8TAR5 Q99834 Q53EL6 |
| Accessions | AAB42218 EAW49552 EAW49553 EAW49554 Q53EL6 AK223623 BAD97343 AK296753 BAG59336 AK312540 BAG35439 AK315295 BAG37701 AL049932 BC015036 AAH15036 BC026104 AAH26104 BC031049 AAH31049 BI910668 BX537500 BX641168 BX647834 DB241608 DQ891645 ABM82571 DQ894834 ABM85760 U96628 AAB67706 NM_001199492 NP_001186421 NM_014456 NP_055271 NM_145341 NP_663314 |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum. |
| Tissue Specificity | Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269|PubMed:10632927, ECO:0000269|PubMed:12898601, ECO:0000269|PubMed:16449643}. |
| Top Pathways | MicroRNAs in cancer, Proteoglycans in cancer |