PDCD4

Gene Symbol	PDCD4
Entrez Gene	27250
Alt Symbol	H731
Species	Human
Gene Type	protein-coding
Description	programmed cell death 4 (neoplastic transformation inhibitor)
Other Description	neoplastic transformation inhibitor protein|nuclear antigen H731|programmed cell death protein 4|protein 197/15a
Swissprots	B2RCV4 Q6PJI5 B5ME91 Q5VZS6 O15501 Q8TAR5 Q99834 Q53EL6
Accessions	AAB42218 EAW49552 EAW49553 EAW49554 Q53EL6 AK223623 BAD97343 AK296753 BAG59336 AK312540 BAG35439 AK315295 BAG37701 AL049932 BC015036 AAH15036 BC026104 AAH26104 BC031049 AAH31049 BI910668 BX537500 BX641168 BX647834 DB241608 DQ891645 ABM82571 DQ894834 ABM85760 U96628 AAB67706 NM_001199492 NP_001186421 NM_014456 NP_055271 NM_145341 NP_663314
Function	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
Tissue Specificity	Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269|PubMed:10632927, ECO:0000269|PubMed:12898601, ECO:0000269|PubMed:16449643}.
Top Pathways	MicroRNAs in cancer, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDCD4 full length protein - ab112409 from Abcam Category Protein Source Wheat germ Species Human

Human PDCD4 full length protein - ab117475 from Abcam Category Protein Source E. coli Species Human

Human PDCD4 peptide - ab45261 from Abcam Category Peptide

Human PDCD4 peptide - ab45262 from Abcam Category Peptide

Human PDCD4 protein fragment - ab172822 from Abcam Category Protein Source E. coli Species Human

PDCD4 Antibody Blocking Peptide - LS-E2877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDCD4 Antibody Blocking Peptide - LS-E10640 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDCD4 Antibody Blocking Peptide - LS-E30285 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PDCD4 Antibody Blocking Peptide - LS-E27919 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDCD4 Antibody Blocking Peptide - LS-E27920 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDCD4 Recombinant Protein - H00027250-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PDCD4 Protein - NBC1-18506 from Novus Biologicals Category Protein Prices $329.00 Sizes 100 µg Source E.coli Species Human

PDCD4 Blocking Peptide - NBP1-76738PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PDCD4-Antibody-Center-Blocking-peptide - BP14001c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDCD4 Protein (OPPA01754) - OPPA01754 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human PDCD4 R protein - orb163499 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

PDCD4 Immunizing peptide - orb66400 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PDCD4 Blocking Peptide - 33R-6551 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDCD4 protein - 30R-1142 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

PDCD4 Peptide - AC21-2692-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDCD4 Peptide - AC21-2693-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDCD4 (1-469) - AR09066PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PDCD4 (1-469) - AR09066PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PDCD4 - H00027250-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDCD4 - H00027250-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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