PDCD4

Gene Symbol	PDCD4
Entrez Gene	27250
Alt Symbol	H731
Species	Human
Gene Type	protein-coding
Description	programmed cell death 4 (neoplastic transformation inhibitor)
Other Description	neoplastic transformation inhibitor protein|nuclear antigen H731|programmed cell death protein 4|protein 197/15a
Swissprots	B2RCV4 Q6PJI5 B5ME91 Q5VZS6 O15501 Q8TAR5 Q99834 Q53EL6
Accessions	AAB42218 EAW49552 EAW49553 EAW49554 Q53EL6 AK223623 BAD97343 AK296753 BAG59336 AK312540 BAG35439 AK315295 BAG37701 AL049932 BC015036 AAH15036 BC026104 AAH26104 BC031049 AAH31049 BI910668 BX537500 BX641168 BX647834 DB241608 DQ891645 ABM82571 DQ894834 ABM85760 U96628 AAB67706 NM_001199492 NP_001186421 NM_014456 NP_055271 NM_145341 NP_663314
Function	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
Tissue Specificity	Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269|PubMed:10632927, ECO:0000269|PubMed:12898601, ECO:0000269|PubMed:16449643}.
Top Pathways	MicroRNAs in cancer, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-PDCD4 (Ser67) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1425 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.312-20 ng/ml

Mouse/Human/Rat Phospho-PDCD4 (Ser457) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1426 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.312-20 ng/ml

Mouse/Human/Rat PDCD4 ELISA Kit (Cell-Based ELISA) - LS-F2229 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.312-20 ng/ml

Human PDCD4 ELISA Kit (Sandwich ELISA) - LS-F12280 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Programmed cell death 4 ( PDCD4), Human, ELISA Kit - CSB-E13638h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Programmed cell death protein 4, PDCD4, Human, ELISA Kit - E2393h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

programmed cell death 4 (neoplastic transformation inhibitor) , ELISA Kit - MBS941857 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PDCD4 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0.156 ng/ml -10 ng/ml.

PDCD4 Colorimetric Cell-Based ELISA Kit - CB5541 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PDCD4 (Phospho-Ser67) Colorimetric Cell-Based ELISA Kit - CBP1457 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PDCD4 (Phospho-Ser457) Colorimetric Cell-Based ELISA Kit - CBP1458 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human programmed cell death 4 ( PDCD4) ELISA Kit - CSB-E13638h from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Mouse PDCD4 ELISA Kit (Custom ELISA) - LS-F19748 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Rat PDCD4 ELISA Kit (Custom ELISA) - LS-F19747 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Chicken PDCD4 ELISA Kit (Custom ELISA) - LS-F19746 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Programmed Cell Death Protein 4 (PDCD4), ELISA Kit - MBS2025520 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of PDCD4 is typically less than 0.065ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

ELISA Kit for Programmed Cell Death Protein 4 (PDCD4) - SEL108Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.065ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Programmed Cell Death Protein 4 (PDCD4) - SEL108Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.065ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PDCD4 ELISA Kit (Sandwich ELISA) - LS-F25579 from LifeSpan Bioscience Category ELISA Kit Prices $850.00 Sizes 1 plate Sensitivity 0.065 ng/ml Range 0.312-20 ng/ml

PDCD4 ELISA Kit - DEIA-XYA1419 from Creative Diagnostics Category ELISA Kit

PDCD4 (Phospho-Ser457) ELISA Kit - DEIA-XYA1420 from Creative Diagnostics Category ELISA Kit

PDCD4 (Phospho-Ser67) ELISA Kit - DEIA-XYA1421 from Creative Diagnostics Category ELISA Kit

PDCD4 - EKH4436 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

PDCD4 ELISA Kit (Human) : 96 Wells (OKEH01644) - OKEH01644 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.13 ng/mL Range 0.312 - 20 ng/mL

Human PDCD4 ELISA Kit - E031003 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PDCD4 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the m

Human Programmed cell death protein 4 ELISA Kit - EK4513 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 5.2 pg/mL Range 15.6-1000 pg/mL

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