PDCD4

Gene Symbol PDCD4
Entrez Gene 27250
Alt Symbol H731
Species Human
Gene Type protein-coding
Description programmed cell death 4 (neoplastic transformation inhibitor)
Other Description neoplastic transformation inhibitor protein|nuclear antigen H731|programmed cell death protein 4|protein 197/15a
Swissprots B2RCV4 Q6PJI5 B5ME91 Q5VZS6 O15501 Q8TAR5 Q99834 Q53EL6
Accessions AAB42218 EAW49552 EAW49553 EAW49554 Q53EL6 AK223623 BAD97343 AK296753 BAG59336 AK312540 BAG35439 AK315295 BAG37701 AL049932 BC015036 AAH15036 BC026104 AAH26104 BC031049 AAH31049 BI910668 BX537500 BX641168 BX647834 DB241608 DQ891645 ABM82571 DQ894834 ABM85760 U96628 AAB67706 NM_001199492 NP_001186421 NM_014456 NP_055271 NM_145341 NP_663314
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
Tissue Specificity Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. {ECO:0000269|PubMed:10632927, ECO:0000269|PubMed:12898601, ECO:0000269|PubMed:16449643}.
Top Pathways MicroRNAs in cancer, Proteoglycans in cancer

Pdcd-4 CRISPR/Cas9 KO Plasmid (h) - sc-401743 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 HDR Plasmid (h) - sc-401743-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 Double Nickase Plasmid (h) - sc-401743-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 Double Nickase Plasmid (h2) - sc-401743-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 CRISPR Activation Plasmid (h) - sc-401743-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 CRISPR Activation Plasmid (h2) - sc-401743-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 Lentiviral Activation Particles (h) - sc-401743-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 Lentiviral Activation Particles (h2) - sc-401743-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pdcd-4 siRNA (h) - sc-106389 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pdcd-4 shRNA Plasmid (h) - sc-106389-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pdcd-4 shRNA (h) Lentiviral Particles - sc-106389-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU070821 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16519 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16519 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PDCD4 siRNA (Human) - CRH9043 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PDCD4 (NM_014456.4) - SHH372212 from Creative biogene

Category siRNA
Species Reactivities Human

Human PDCD4 siRNA - orb269545 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PDCD4 shRNA Plasmid (Human) - CHH9043 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PDCD4 miRNA 3'UTR clone - MiUTR3H-10111 from Creative biogene

Species Reactivities Human

PDCD4 miRNA 3'UTR clone - MiUTR3H-10112 from Creative biogene

Species Reactivities Human
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