| Gene Symbol | SRD5A3 |
|---|---|
| Entrez Gene | 79644 |
| Alt Symbol | CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | steroid 5 alpha-reductase 3 |
| Other Description | 3-oxo-5-alpha-steroid 4-dehydrogenase 3|S5AR 3|SR type 3|polyprenol reductase|probable polyprenol reductase |
| Swissprots | Q4W5Q6 Q9H8P0 |
| Accessions | AAY40904 EAX05465 Q9H8P0 AK023414 BAB14568 BC002480 AAH02480 CR457312 CAG33593 CX763068 DB532427 HQ447832 ADQ32316 XM_005265766 XP_005265823 XM_005265767 XP_005265824 NM_024592 NP_078868 |
| Function | Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}. |
| Tissue Specificity | Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. {ECO:0000269|PubMed:17986282}. |
| Top Pathways | Steroid hormone biosynthesis |
steroid 5 alpha-reductase 3 - MBS9329272 from MyBioSource
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Human SRD5A3 ELISA Kit - E030867 from Biobool
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9366855 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9346666 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9358791 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9362203 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9353776 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9362568 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9357126 from MyBioSource
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Probable Polyprenol Reductase (SRD5A3), ELISA Kit - MBS9376344 from MyBioSource
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