SRD5A3

Gene Symbol	SRD5A3
Entrez Gene	79644
Alt Symbol	CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
Species	Human
Gene Type	protein-coding
Description	steroid 5 alpha-reductase 3
Other Description	3-oxo-5-alpha-steroid 4-dehydrogenase 3|S5AR 3|SR type 3|polyprenol reductase|probable polyprenol reductase
Swissprots	Q4W5Q6 Q9H8P0
Accessions	AAY40904 EAX05465 Q9H8P0 AK023414 BAB14568 BC002480 AAH02480 CR457312 CAG33593 CX763068 DB532427 HQ447832 ADQ32316 XM_005265766 XP_005265823 XM_005265767 XP_005265824 NM_024592 NP_078868
Function	Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}.
Tissue Specificity	Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. {ECO:0000269|PubMed:17986282}.
Top Pathways	Steroid hormone biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SRD5A3 full length protein - ab164060 from Abcam Category Protein Source Wheat germ Species Human

SRD5A2L / SRD5A3 Antibody Blocking Peptide - LS-E7797 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRD5A3 Recombinant Protein - H00079644-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

SRD5A3-Antibody-C-term-Blocking-peptide - BP5276b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRD5A3 Blocking Peptide - 33R-3408 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SRD5A3 - H00079644-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SRD5A3 fusion protein - ag16829 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SRD5A3 fusion protein - ag13873 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Probable polyprenol reductase (CBG09584), Recombinant Protein - MBS1109557 from MyBioSource Category Protein Prices $1,625.00, $2,085.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Caenorhabditis

Probable polyprenol reductase (SRD5A3), Recombinant Protein - MBS1122054 from MyBioSource Category Protein Prices $1,645.00, $2,105.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell

SRD5A3 Recombinant Protein Antigen - NBP1-82259PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SRD5A3 Peptide, Human - M34GP15140H from Creative Peptides Category Peptide Source Synthetic. Species Human

Probable polyprenol reductase, Recombinant Protein - MBS7039320 from MyBioSource Category Protein Prices $1,120.00, $2,105.00, $3,315.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Caenorhabditis

Probable polyprenol reductase (SRD5A3), Recombinant Protein - MBS7030422 from MyBioSource Category Protein Prices $1,130.00, $2,115.00, $3,325.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression

Probable polyprenol reductase (SRD5A3), Recombinant Protein - MBS7030424 from MyBioSource Category Protein Prices $1,130.00, $2,115.00, $3,325.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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