SRD5A3

Gene Symbol SRD5A3
Entrez Gene 79644
Alt Symbol CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
Species Human
Gene Type protein-coding
Description steroid 5 alpha-reductase 3
Other Description 3-oxo-5-alpha-steroid 4-dehydrogenase 3|S5AR 3|SR type 3|polyprenol reductase|probable polyprenol reductase
Swissprots Q4W5Q6 Q9H8P0
Accessions AAY40904 EAX05465 Q9H8P0 AK023414 BAB14568 BC002480 AAH02480 CR457312 CAG33593 CX763068 DB532427 HQ447832 ADQ32316 XM_005265766 XP_005265823 XM_005265767 XP_005265824 NM_024592 NP_078868
Function Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}.
Tissue Specificity Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. {ECO:0000269|PubMed:17986282}.
Top Pathways Steroid hormone biosynthesis

SRD5A2L (G-16) - sc-248710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SRD5A3 antibody - ab104063 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SRD5A3 antibody (ab104063) at 1/100 dilution + K562 cell line lysates at 35 µg

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311, AP) - LS-C270338 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311, APC) - LS-C270337 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311, Azide-free, HRP) - LS-C270341 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311, Biotin) - LS-C270339 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311, FITC) - LS-C270340 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311, PE) - LS-C270342 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa288-318) - LS-C325375 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2L / SRD5A3 Antibody (aa38-87) - LS-C81470 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-SRD5A2L / SRD5A3 Antibody (aa283-311) - LS-C161493 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SRD5A3 Antibody IHC of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

SRD5A3 Antibody - NBP1-69612 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SRD5A3 Antibody [NBP1-69612] - This Anti-SRD5A3 antibody was used in Western Blot of Fetal Muscle tissue lysate at a concentration of 1ug/ml.

SRD5A3 Antibody - NBP1-82259 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SRD5A3 Antibody [NBP1-82259] - Staining of human cell line A-431 shows positivity in plasma membrane and cytoplasm.

Anti-SRD5A3 antibody produced in rabbit - HPA027006 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SRD5A2L: <B>Cat. No. HPA027006</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in subset of glandular cells.

Anti-SRD5A3 antibody produced in rabbit - SAB2102296 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SRD5A3: <B>Cat. No.SAB2102296</B>: SRD5A3 in Fetal Muscle tissue lysate with SRD5A3 antibody at 1.0 μg/mL.

SRD5A3 antibody - N-terminal region (ARP49838_P050) - ARP49838_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SRD5A3 Antibody - C-terminal region (OAAB02693) - OAAB02693 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SRD5A3-Antibody-C-term - AP5276b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SRD5A3 Antibody (C-term) (Cat. #AP5276b) western blot analysis in 293,LNCaP,PC-3,NCI-H292 cell line lysates (35ug/lane).This demonstrates the SRD5A3 antibody detected the SRD5A3 protein (arrow).

SRD5A3 antibody - 70R-7438 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SRD5A3 Antibody - abx032467 from Abbexa

Host Rabbit
Clonality Polyclonal

Rabbit Anti-Human SRD5A3 (C-term) - 102-16457 from RayBiotech

Host Rabbit
SRD5A3 Antibody (C-term) (Cat# 102-16457) western blot analysis in 293,LNCaP,PC-3,NCI-H292 cell line lysates (35ug/lane).This demonstrates the SRD5A3 antibody detected the SRD5A3 protein (arrow).

SRD5A3 antibody (C-term) - STJ49458 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB26598

SRD5A3 Antibody - GWB-MR672F from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SRD5A3 monoclonal antibody - DCABH-16971 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

SRD5A3 Polyclonal Antibody - PA5-25200 from Thermo Fisher Scientific

Prices $349.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis using a SRD5A3 polyclonal antibody (Product # PA5-25200) in NCI-H292 (lane 1), 293 (lane 2) cell lysates (35ug per lane).
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