SRD5A3

Gene Symbol SRD5A3
Entrez Gene 79644
Alt Symbol CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
Species Human
Gene Type protein-coding
Description steroid 5 alpha-reductase 3
Other Description 3-oxo-5-alpha-steroid 4-dehydrogenase 3|S5AR 3|SR type 3|polyprenol reductase|probable polyprenol reductase
Swissprots Q4W5Q6 Q9H8P0
Accessions AAY40904 EAX05465 Q9H8P0 AK023414 BAB14568 BC002480 AAH02480 CR457312 CAG33593 CX763068 DB532427 HQ447832 ADQ32316 XM_005265766 XP_005265823 XM_005265767 XP_005265824 NM_024592 NP_078868
Function Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:17986282, ECO:0000269|PubMed:20637498}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:20637498}; Multi-pass membrane protein {ECO:0000305|PubMed:20637498}.
Tissue Specificity Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. {ECO:0000269|PubMed:17986282}.
Top Pathways Steroid hormone biosynthesis

SRD5A2L CRISPR/Cas9 KO Plasmid (h) - sc-413197 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L HDR Plasmid (h) - sc-413197-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L Double Nickase Plasmid (h) - sc-413197-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L Double Nickase Plasmid (h2) - sc-413197-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L CRISPR Activation Plasmid (h) - sc-413197-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L CRISPR Activation Plasmid (h2) - sc-413197-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L Lentiviral Activation Particles (h) - sc-413197-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L Lentiviral Activation Particles (h2) - sc-413197-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SRD5A2L siRNA (h) - sc-89215 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRD5A2L shRNA Plasmid (h) - sc-89215-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SRD5A2L shRNA (h) Lentiviral Particles - sc-89215-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU111731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20562 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20562 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08577 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08577

SRD5A3 siRNA (Human) - CRJ2451 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SRD5A3 - MBS8239496 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SRD5A3 (NM_024592.4) - SHH417716 from Creative biogene

Category siRNA
Species Reactivities Human

Human SRD5A3 siRNA - orb272952 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SRD5A3 shRNA Plasmid (Human) - CHJ2451 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SRD5A3 miRNA 3'UTR clone - MiUTR3H-12060 from Creative biogene

Species Reactivities Human
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