| Gene Symbol |
PRKAG3
|
| Entrez Gene |
53632
|
| Alt Symbol |
AMPKG3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
|
| Other Description |
5'-AMP-activated protein kinase subunit gamma-3|5'-AMP-activated protein kinase, gamma-3 subunit|AMPK gamma-3 chain|AMPK gamma3|AMPK subunit gamma-3
|
| Swissprots |
Q4V779 Q9UGI9 Q9NRL1 Q4QQG8
|
| Accessions |
CCQ43548 EAW70656 EAW70657 Q9UGI9 AA256383 AF214519 AAF73987 AJ249977 CAB65117 AK300078 BAG61882 AK300687 BAG62370 AK309865 BC098102 AAH98102 BC098255 AAH98255 BC098277 AAH98277 BC098306 AAH98306 CD628195 W94830 NM_017431 NP_059127
|
| Function |
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread
|
| Tissue Specificity |
Skeletal muscle, with weak expression in heart and pancreas.
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm
|