| Gene Symbol | PRKAG3 |
|---|---|
| Entrez Gene | 53632 |
| Alt Symbol | AMPKG3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, AMP-activated, gamma 3 non-catalytic subunit |
| Other Description | 5'-AMP-activated protein kinase subunit gamma-3|5'-AMP-activated protein kinase, gamma-3 subunit|AMPK gamma-3 chain|AMPK gamma3|AMPK subunit gamma-3 |
| Swissprots | Q4V779 Q9UGI9 Q9NRL1 Q4QQG8 |
| Accessions | CCQ43548 EAW70656 EAW70657 Q9UGI9 AA256383 AF214519 AAF73987 AJ249977 CAB65117 AK300078 BAG61882 AK300687 BAG62370 AK309865 BC098102 AAH98102 BC098255 AAH98255 BC098277 AAH98277 BC098306 AAH98306 CD628195 W94830 NM_017431 NP_059127 |
| Function | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread |
| Tissue Specificity | Skeletal muscle, with weak expression in heart and pancreas. |
| Top Pathways | Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm |