PRKAG3
| Gene Symbol | PRKAG3 |
|---|---|
| Entrez Gene | 53632 |
| Alt Symbol | AMPKG3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, AMP-activated, gamma 3 non-catalytic subunit |
| Other Description | 5'-AMP-activated protein kinase subunit gamma-3|5'-AMP-activated protein kinase, gamma-3 subunit|AMPK gamma-3 chain|AMPK gamma3|AMPK subunit gamma-3 |
| Swissprots | Q4V779 Q9UGI9 Q9NRL1 Q4QQG8 |
| Accessions | CCQ43548 EAW70656 EAW70657 Q9UGI9 AA256383 AF214519 AAF73987 AJ249977 CAB65117 AK300078 BAG61882 AK300687 BAG62370 AK309865 BC098102 AAH98102 BC098255 AAH98255 BC098277 AAH98277 BC098306 AAH98306 CD628195 W94830 NM_017431 NP_059127 |
| Function | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread |
| Tissue Specificity | Skeletal muscle, with weak expression in heart and pancreas. |
| Top Pathways | Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm |
AMPKγ3 CRISPR/Cas9 KO Plasmid (h) - sc-403280 from Santa Cruz Biotechnology
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AMPKγ3 HDR Plasmid (h) - sc-403280-HDR from Santa Cruz Biotechnology
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AMPKγ3 Double Nickase Plasmid (h) - sc-403280-NIC from Santa Cruz Biotechnology
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AMPKγ3 Double Nickase Plasmid (h2) - sc-403280-NIC-2 from Santa Cruz Biotechnology
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AMPKγ3 CRISPR Activation Plasmid (h) - sc-403280-ACT from Santa Cruz Biotechnology
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AMPKγ3 CRISPR Activation Plasmid (h2) - sc-403280-ACT-2 from Santa Cruz Biotechnology
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AMPKγ3 Lentiviral Activation Particles (h) - sc-403280-LAC from Santa Cruz Biotechnology
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AMPKγ3 Lentiviral Activation Particles (h2) - sc-403280-LAC-2 from Santa Cruz Biotechnology
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AMPKγ3 siRNA (h) - sc-38933 from Santa Cruz Biotechnology
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AMPKγ3 shRNA Plasmid (h) - sc-38933-SH from Santa Cruz Biotechnology
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AMPKγ3 shRNA (h) Lentiviral Particles - sc-38933-V from Santa Cruz Biotechnology
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PRKAG3 RNAi - H00053632-R02 from Novus Biologicals
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MISSION® esiRNA - EHU121771 from Sigma-Aldrich
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MISSION® siRNA - SIHK1803 from Sigma-Aldrich
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MISSION® siRNA - SIHK1804 from Sigma-Aldrich
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MISSION® siRNA - SIHK1805 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17417 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17417 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06419 from Sigma-Aldrich
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PRKAG3 siRNA (Human) - CRH9977 from Cohesion Biosciences
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shRNA set against Human PRKAG3 (NM_017431.2) - SHH382720 from Creative biogene
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shRNA set against Human PRKAG3(NM_017431.2) - SHR140016 from Creative biogene
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Human PRKAG3 siRNA - orb270479 from Biorbyt
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PRKAG3 shRNA Plasmid (Human) - CHH9977 from Cohesion Biosciences
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PRKAG3 miRNA 3'UTR clone - MiUTR1H-08266 from Creative biogene
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