PRKAG3

Gene Symbol	PRKAG3
Entrez Gene	53632
Alt Symbol	AMPKG3
Species	Human
Gene Type	protein-coding
Description	protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Other Description	5'-AMP-activated protein kinase subunit gamma-3|5'-AMP-activated protein kinase, gamma-3 subunit|AMPK gamma-3 chain|AMPK gamma3|AMPK subunit gamma-3
Swissprots	Q4V779 Q9UGI9 Q9NRL1 Q4QQG8
Accessions	CCQ43548 EAW70656 EAW70657 Q9UGI9 AA256383 AF214519 AAF73987 AJ249977 CAB65117 AK300078 BAG61882 AK300687 BAG62370 AK309865 BC098102 AAH98102 BC098255 AAH98255 BC098277 AAH98277 BC098306 AAH98306 CD628195 W94830 NM_017431 NP_059127
Function	AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread
Tissue Specificity	Skeletal muscle, with weak expression in heart and pancreas.
Top Pathways	Non-alcoholic fatty liver disease (NAFLD), Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AMPK gamma 3 full length protein - ab162696 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

PRKAG3 / AMPK Gamma 3 Antibody Blocking Peptide - LS-E4546 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAG3 / AMPK Gamma 3 Antibody Blocking Peptide - LS-E8643 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKAG3 / AMPK Gamma 3 Antibody Blocking Peptide - LS-E23356 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PRKAG3 Protein - H00053632-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PRKAG3 Peptide - P2147 from Novus Biologicals Category Peptide Species Human

PRKAG3-Antibody-C-term-Blocking-Peptide - BP16887b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKAG3-Antibody-Center-Blocking-Peptide - BP7050c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKAG3 Immunizing peptide - orb17158 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PRKAG3 Peptide - AC21-1513-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AMPK gamma-3 chain / AMPKG3 - H00053632-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AMPK gamma-3 chain / AMPKG3 - H00053632-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PRKAG3 Peptide - 46-941P from ProSci Category Peptide

PRKAG3 fusion protein - ag15826 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PRKAG3 fusion protein - ag17622 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Protein Kinase, AMP Activated Gamma 3 (PRKAg3) - RPG288Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human 5'-AMP-activated protein kinase subunit gamma-3(PRKAG3) - CSB-YP883379HU CSB-EP883379HU CSB-BP883379HU CSB-MP883379HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PRKAG3 Protein - abx164543 from Abbexa Category Protein Species Human

5'-AMP-activated protein kinase subunit gamma-3 (PRKAG3), Recombinant Protein - MBS1361737 from MyBioSource Category Protein Prices $1,275.00, $1,275.00, $1,495.00, $1,495.00, $2,085.00, $2,085.00, $2,550.00, $2,550.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PRKAG3, Peptide - MBS426609 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Bovine

PRKAG3 Peptide, Human - M34GP12392H from Creative Peptides Category Peptide Source Synthetic. Species Human

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