HINT1

Gene Symbol HINT1
Entrez Gene 3094
Alt Symbol HINT, NMAN, PKCI-1, PRKCNH1
Species Human
Gene Type protein-coding
Description histidine triad nucleotide binding protein 1
Other Description adenosine 5'-monophosphoramidase|histidine triad nucleotide-binding protein 1|protein kinase C inhibitor 1|protein kinase C-interacting protein 1
Swissprots Q9H5W8 P49773
Accessions EAW62376 P49773 AA076103 AK026557 BAB15500 AK054976 AK056902 BC001287 AAH01287 BC007090 AAH07090 BC028300 BF967059 BG527380 BG708765 BG942577 CD639104 CK002748 CN290239 CR457048 CAG33329 DA352878 DB125655 DB289264 U27143 AAA82926 U51004 AAC71077 XM_011543356 XP_011541658 NM_005340 NP_005331 NR_024610 NR_024611 NR_073488
Function Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-
Subcellular Location Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
Tissue Specificity Widely expressed.

Hint1 (B-5) - sc-271790 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Hint1 (B-5): sc-271790. Western blot analysis of Hint1 expression in Jurkat (A) and Hep G2 (B) whole cell lysates.

Hint1 (C-16) - sc-107592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Hint1 (H-5) - sc-365015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Hint1 (H-5): sc-365015. Western blot analysis of Hint1 expression in Jurkat (A) and HEK293 (B) whole cell lysates.

Hint1 (H-40) - sc-68908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-HINT1 antibody - ab199666 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HINT1 antibody (ab199666) at 1/500 dilutionLane 1 : 293T cell line lysateLane 2 : MCF7 cell line lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-HINT1 antibody - ab77086 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-HINT1 antibody (ab77086) at 1 µg/mlLane 2 : Anti-HINT1 antibody (ab77086) at 2 µg/mlLane 1 : Jurkat lysateLane 2 : Jurkat lysateLysates/proteins at 15 µg per lane.

Anti-HINT1 antibody - ab136835 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HINT1 antibody (ab136835) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-HINT1 antibody - ab67680 from Abcam

Host Mouse
Clonality Polyclonal
All lanes : Anti-HINT1 antibody (ab67680) at 1/500 dilutionLane 1 : HINT1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-HINT1 antibody [EPR5108] - ab124912 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5108
All lanes : Anti-HINT1 antibody [EPR5108] (ab124912) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : MCF7 cell lysateLane 3 : HepG2 cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-HINT1 antibody [EPR5109] - ab109319 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5109
All lanes : Anti-HINT1 antibody [EPR5109] (ab109319) at 1/1000 dilutionLane 1 : 293T cell lysate Lane 2 : Jurkat cell lysate Lane 3 : Raji cell lysate Lane 4 : HeLa cell lysate Lysates/proteins at 10 µg per lane.

Anti-HINT / HINT1 Antibody (Internal, clone EPR5108) IHC-plus™ - LS-B6705 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5108
Anti-HINT1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6705 dilution 1:50.

Anti-HINT / HINT1 Antibody (Internal, clone EPR5109) - LS-C138374 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5109
IHC of paraffin-embedded human colon tissue using anti-Hint1 antibody.

Anti-HINT / HINT1 Antibody (clone 2D7) - LS-C133892 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D7
Immunoperoxidase of monoclonal antibody to HINT1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

Anti-HINT / HINT1 Antibody (N-Terminus) IHC-plus™ - LS-B5852 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HINT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5852 concentration 2.5 ug/ml.

Anti-HINT / HINT1 Antibody (aa38-87) IHC-plus™ - LS-B5853 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HINT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5853 concentration 2.5 ug/ml.

Anti-HINT / HINT1 Antibody (Internal) IHC-plus™ - LS-B4989 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HINT1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4989 concentration 5 ug/ml.

Anti-HINT / HINT1 Antibody (Asn99) - LS-C192059 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HINT / HINT1 Antibody (aa50-99) - LS-C292056 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HINT / HINT1 Antibody (aa71-120) - LS-C118912 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using HINT1 Antibody. The picture on the right is treated with the synthesized peptide.

HINT1 Antibody - NBP1-83257 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HINT1 Antibody [NBP1-83257] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

HINT1 Antibody - NBP1-76944 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HINT1 Antibody [NBP1-76944] - Jurkat lysate with HINT1 antibody at (A) 1 and (B) 2 ug/mL.

HINT1 Antibody (2D7) - H00003094-M05 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D7

HINT1 Antibody - H00003094-A02 from Novus Biologicals

Prices $269.00
Sizes 100 µg
Host Mouse
Clonality Polyclonal

HINT1 Antibody - H00003094-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

HINT1 Polyclonal Antibody - bs-10228R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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