HINT1

Gene Symbol	HINT1
Entrez Gene	3094
Alt Symbol	HINT, NMAN, PKCI-1, PRKCNH1
Species	Human
Gene Type	protein-coding
Description	histidine triad nucleotide binding protein 1
Other Description	adenosine 5'-monophosphoramidase|histidine triad nucleotide-binding protein 1|protein kinase C inhibitor 1|protein kinase C-interacting protein 1
Swissprots	Q9H5W8 P49773
Accessions	EAW62376 P49773 AA076103 AK026557 BAB15500 AK054976 AK056902 BC001287 AAH01287 BC007090 AAH07090 BC028300 BF967059 BG527380 BG708765 BG942577 CD639104 CK002748 CN290239 CR457048 CAG33329 DA352878 DB125655 DB289264 U27143 AAA82926 U51004 AAC71077 XM_011543356 XP_011541658 NM_005340 NP_005331 NR_024610 NR_024611 NR_073488
Function	Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-
Subcellular Location	Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
Tissue Specificity	Widely expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HINT1 full length protein - ab87362 from Abcam Category Protein Source E. coli Species Human

Human HINT1 peptide - ab71589 from Abcam Category Peptide

HINT / HINT1 Antibody Blocking Peptide - LS-E19741 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HINT / HINT1 Antibody Blocking Peptide - LS-E19742 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HINT / HINT1 Antibody Blocking Peptide - LS-E30579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HINT1 Partial Recombinant Protein - H00003094-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

HINT1 Recombinant Protein - H00003094-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human HINT1 Protein - NBC1-28612 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

HINT1 Peptide - NBP1-76944PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

HINT1 Protein (OPPA02063) - OPPA02063 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Histidine Triad Nucleotide Binding Protein 1 protein - orb81160 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

14.3.3 beta protein - 30R-1163 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

HINT1 Blocking Peptide - 33R-1088 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HINT1 Blocking Peptide - 33R-1729 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HINT1 protein - 30R-1327 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

HINT1 (1-126) - AR09208PU-L from Acris Antibodies Category Protein Prices $785.00 Sizes 500 µg Source E. coli Species Human

HINT1 (1-126) - AR09208PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

HINT1 - H00003094-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

HINT1 - H00003094-P01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source in vitro transl. Species Human

HINT1 - H00003094-P01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Source in vitro transl. Species Human

HINT1 - H00003094-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

HINT1 - H00003094-Q01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source in vitro transl. Species Human

HINT1 - H00003094-Q01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Source in vitro transl. Species Human

HINT1 Control Peptide - AP30394CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Histidine Triad Nucleotide Binding Protein 1, Human Recombinant - 228-10709-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

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