HINT1

Gene Symbol	HINT1
Entrez Gene	3094
Alt Symbol	HINT, NMAN, PKCI-1, PRKCNH1
Species	Human
Gene Type	protein-coding
Description	histidine triad nucleotide binding protein 1
Other Description	adenosine 5'-monophosphoramidase|histidine triad nucleotide-binding protein 1|protein kinase C inhibitor 1|protein kinase C-interacting protein 1
Swissprots	Q9H5W8 P49773
Accessions	EAW62376 P49773 AA076103 AK026557 BAB15500 AK054976 AK056902 BC001287 AAH01287 BC007090 AAH07090 BC028300 BF967059 BG527380 BG708765 BG942577 CD639104 CK002748 CN290239 CR457048 CAG33329 DA352878 DB125655 DB289264 U27143 AAA82926 U51004 AAC71077 XM_011543356 XP_011541658 NM_005340 NP_005331 NR_024610 NR_024611 NR_073488
Function	Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-
Subcellular Location	Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
Tissue Specificity	Widely expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HINT1 overexpression lysate - LY417372 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HINT1 293 Cell Lysate - 408127 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

HINT1 Overexpression Lysate (Denatured) - H00003094-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

HINT1 Overexpression Lysate (Native) - NBL1-11545 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HINT1 Over-expression Lysate Product - GWB-E30B33 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human HINT1 Knockdown Stable Cell Line - CSC-DC006996 from Creative biogene Category Cell Line Species Human

HINT1 KO Cell Lysate-HeLa - CLKO-1049 from Creative biogene Category Cell Lysate

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