| Gene Symbol |
HINT1
|
| Entrez Gene |
3094
|
| Alt Symbol |
HINT, NMAN, PKCI-1, PRKCNH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histidine triad nucleotide binding protein 1
|
| Other Description |
adenosine 5'-monophosphoramidase|histidine triad nucleotide-binding protein 1|protein kinase C inhibitor 1|protein kinase C-interacting protein 1
|
| Swissprots |
Q9H5W8 P49773
|
| Accessions |
EAW62376 P49773 AA076103 AK026557 BAB15500 AK054976 AK056902 BC001287 AAH01287 BC007090 AAH07090 BC028300 BF967059 BG527380 BG708765 BG942577 CD639104 CK002748 CN290239 CR457048 CAG33329 DA352878 DB125655 DB289264 U27143 AAA82926 U51004 AAC71077 XM_011543356 XP_011541658 NM_005340 NP_005331 NR_024610 NR_024611 NR_073488
|
| Function |
Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
|
| Tissue Specificity |
Widely expressed.
|