| Gene Symbol | HINT1 |
|---|---|
| Entrez Gene | 3094 |
| Alt Symbol | HINT, NMAN, PKCI-1, PRKCNH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | histidine triad nucleotide binding protein 1 |
| Other Description | adenosine 5'-monophosphoramidase|histidine triad nucleotide-binding protein 1|protein kinase C inhibitor 1|protein kinase C-interacting protein 1 |
| Swissprots | Q9H5W8 P49773 |
| Accessions | EAW62376 P49773 AA076103 AK026557 BAB15500 AK054976 AK056902 BC001287 AAH01287 BC007090 AAH07090 BC028300 BF967059 BG527380 BG708765 BG942577 CD639104 CK002748 CN290239 CR457048 CAG33329 DA352878 DB125655 DB289264 U27143 AAA82926 U51004 AAC71077 XM_011543356 XP_011541658 NM_005340 NP_005331 NR_024610 NR_024611 NR_073488 |
| Function | Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin- |
| Subcellular Location | Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization. |
| Tissue Specificity | Widely expressed. |
Hint1 CRISPR/Cas9 KO Plasmid (h) - sc-418276 from Santa Cruz Biotechnology
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Hint1 HDR Plasmid (h) - sc-418276-HDR from Santa Cruz Biotechnology
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Hint1 Double Nickase Plasmid (h) - sc-418276-NIC from Santa Cruz Biotechnology
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Hint1 Double Nickase Plasmid (h2) - sc-418276-NIC-2 from Santa Cruz Biotechnology
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Hint1 CRISPR Activation Plasmid (h) - sc-418276-ACT from Santa Cruz Biotechnology
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Hint1 CRISPR Activation Plasmid (h2) - sc-418276-ACT-2 from Santa Cruz Biotechnology
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Hint1 Lentiviral Activation Particles (h) - sc-418276-LAC from Santa Cruz Biotechnology
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Hint1 Lentiviral Activation Particles (h2) - sc-418276-LAC-2 from Santa Cruz Biotechnology
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Hint1 siRNA (h) - sc-92005 from Santa Cruz Biotechnology
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Hint1 shRNA Plasmid (h) - sc-92005-SH from Santa Cruz Biotechnology
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Hint1 shRNA (h) Lentiviral Particles - sc-92005-V from Santa Cruz Biotechnology
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HINT1 RNAi - H00003094-R01 from Novus Biologicals
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MISSION® esiRNA - EHU050901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10039 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10039 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00555 from Sigma-Aldrich
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HINT1 siRNA (Human) - CRH2108 from Cohesion Biosciences
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HINT1 - MBS8240926 from MyBioSource
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shRNA set against Human HINT1 (NM_005340.5) - SHH312221 from Creative biogene
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Human HINT1 siRNA - orb262610 from Biorbyt
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HINT1 shRNA Plasmid (Human) - CHH2108 from Cohesion Biosciences
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HINT1 miRNA 3'UTR clone - MiUTR3H-04058 from Creative biogene
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