| Gene Symbol |
NGFRAP1
|
| Entrez Gene |
27018
|
| Alt Symbol |
BEX3, Bex, DXS6984E, HGR74, NADE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nerve growth factor receptor (TNFRSF16) associated protein 1
|
| Other Description |
brain-expressed X-linked protein 3|ovarian granulosa cell 13.0 kDa protein HGR74|p75NTR-associated cell death executor|protein BEX3
|
| Swissprots |
B2RD17 D3DXA3 Q00994 Q5JQT4 Q5JQT5
|
| Accessions |
CBX53811 CBX53812 CBX53813 CCQ43433 EAW54710 EAW54711 EAW54712 Q00994 AF187064 AAF75129 AI929106 AK057859 AK315371 BAG37764 AY833562 AAX40680 BC003190 AAH03190 BC051713 BE395284 BQ068114 CD048295 HQ447887 ADQ32371 M38188 AAA63232 NM_001282674 NP_001269603 NM_014380 NP_055195 NM_206915 NP_996798 NM_206917 NP_996800
|
| Function |
May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. {ECO:0000269|PubMed:15958283}.
|
| Top Pathways |
Neurotrophin signaling pathway
|
![Western Blot: NADE Overexpression Lysate (Adult Normal) [NBP2-10324] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NADE.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2110_NADE%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10324-img0001.jpg)