Gene Symbol | NGFRAP1 |
---|---|
Entrez Gene | 27018 |
Alt Symbol | BEX3, Bex, DXS6984E, HGR74, NADE |
Species | Human |
Gene Type | protein-coding |
Description | nerve growth factor receptor (TNFRSF16) associated protein 1 |
Other Description | brain-expressed X-linked protein 3|ovarian granulosa cell 13.0 kDa protein HGR74|p75NTR-associated cell death executor|protein BEX3 |
Swissprots | B2RD17 D3DXA3 Q00994 Q5JQT4 Q5JQT5 |
Accessions | CBX53811 CBX53812 CBX53813 CCQ43433 EAW54710 EAW54711 EAW54712 Q00994 AF187064 AAF75129 AI929106 AK057859 AK315371 BAG37764 AY833562 AAX40680 BC003190 AAH03190 BC051713 BE395284 BQ068114 CD048295 HQ447887 ADQ32371 M38188 AAA63232 NM_001282674 NP_001269603 NM_014380 NP_055195 NM_206915 NP_996798 NM_206917 NP_996800 |
Function | May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. {ECO:0000250}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity). {ECO:0000250}. |
Tissue Specificity | Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. {ECO:0000269|PubMed:15958283}. |
Top Pathways | Neurotrophin signaling pathway |