| Gene Symbol |
TOLLIP
|
| Entrez Gene |
54472
|
| Alt Symbol |
IL-1RAcPIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
toll interacting protein
|
| Other Description |
adapter protein|toll-interacting protein
|
| Swissprots |
Q9H9E6 Q9H0E2 Q9UJ69 B3KXC6
|
| Accessions |
EAX02433 EAX02434 EAX02435 Q9H0E2 AA861717 AB209541 BAD92778 AJ242972 CAB58118 AK022871 BAB14283 AK090850 BAG52240 AK096693 BAC04844 AK127123 BAG54438 AK315592 BAG37964 AL136835 CAB66769 AM393373 CAL38251 AY730683 AAX22229 BC004420 AAH04420 BC012057 AAH12057 BC018272 AAH18272 BX648136 CR533477 CAG38508 DB039994 DQ891802 ABM82728 DQ894986 ABM85912 XM_011520192 XP_011518494 NM_019009 NP_061882
|
| Function |
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). {ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:25042851}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Top Pathways |
Toll-like receptor signaling pathway
|