TOLLIP

Gene Symbol TOLLIP
Entrez Gene 54472
Alt Symbol IL-1RAcPIP
Species Human
Gene Type protein-coding
Description toll interacting protein
Other Description adapter protein|toll-interacting protein
Swissprots Q9H9E6 Q9H0E2 Q9UJ69 B3KXC6
Accessions EAX02433 EAX02434 EAX02435 Q9H0E2 AA861717 AB209541 BAD92778 AJ242972 CAB58118 AK022871 BAB14283 AK090850 BAG52240 AK096693 BAC04844 AK127123 BAG54438 AK315592 BAG37964 AL136835 CAB66769 AM393373 CAL38251 AY730683 AAX22229 BC004420 AAH04420 BC012057 AAH12057 BC018272 AAH18272 BX648136 CR533477 CAG38508 DB039994 DQ891802 ABM82728 DQ894986 ABM85912 XM_011520192 XP_011518494 NM_019009 NP_061882
Function Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). {ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:25042851}.
Subcellular Location Cytoplasm {ECO:0000305}.
Top Pathways Toll-like receptor signaling pathway

Tollip CRISPR/Cas9 KO Plasmid (h) - sc-402638 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip HDR Plasmid (h) - sc-402638-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip Double Nickase Plasmid (h) - sc-402638-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip Double Nickase Plasmid (h2) - sc-402638-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip CRISPR Activation Plasmid (h) - sc-402638-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip CRISPR Activation Plasmid (h2) - sc-402638-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip Lentiviral Activation Particles (h) - sc-402638-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip Lentiviral Activation Particles (h2) - sc-402638-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tollip siRNA (h) - sc-63332 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tollip shRNA Plasmid (h) - sc-63332-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tollip shRNA (h) Lentiviral Particles - sc-63332-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tollip RNAi - H00054472-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU076191 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21808 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21808 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11624 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11624

TOLLIP siRNA (Human) - CRJ0080 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TOLLIP - MBS8213845 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TOLLIP (NM_019009.3) - SHH432660 from Creative biogene

Category siRNA
Species Reactivities Human

TOLLIP shRNA Plasmid (Human) - CHJ0080 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TOLLIP miRNA 3'UTR clone - MiUTR4H-TG09256 from Creative biogene

Species Reactivities Human
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