TOLLIP

Gene Symbol TOLLIP
Entrez Gene 54472
Alt Symbol IL-1RAcPIP
Species Human
Gene Type protein-coding
Description toll interacting protein
Other Description adapter protein|toll-interacting protein
Swissprots Q9H9E6 Q9H0E2 Q9UJ69 B3KXC6
Accessions EAX02433 EAX02434 EAX02435 Q9H0E2 AA861717 AB209541 BAD92778 AJ242972 CAB58118 AK022871 BAB14283 AK090850 BAG52240 AK096693 BAC04844 AK127123 BAG54438 AK315592 BAG37964 AL136835 CAB66769 AM393373 CAL38251 AY730683 AAX22229 BC004420 AAH04420 BC012057 AAH12057 BC018272 AAH18272 BX648136 CR533477 CAG38508 DB039994 DQ891802 ABM82728 DQ894986 ABM85912 XM_011520192 XP_011518494 NM_019009 NP_061882
Function Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). {ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:25042851}.
Subcellular Location Cytoplasm {ECO:0000305}.
Top Pathways Toll-like receptor signaling pathway

Tollip Antibody - 4748 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SW620, HeLa and COS cells, using Tollip Antibody.

Tollip (H-164) - sc-292758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Tollip (N-17) - sc-27315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tollip (N-17): sc-27315. Western blot analysis of Tollip expression in Jurkat (A), Hep G2 (B), SK-N-MC (C), HeLa (D) and LNCaP (E) whole cell lysates and mouse brain tissue extract (F).

Tollip (k1B17) - sc-136152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Tollip (k1B17): sc-136152. Western blot analysis of Tollip expression in Jurkat whole cell lysate.

Tollip (Kimmy-2) - sc-59720 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Tollip (Kimmy-2): sc-59720. Western blot analysis of Tollip expression in non-transfected: sc-110760 (A) and human Tollip transfected: sc-112320 (B) 293 whole cell lysates.

Anti-Tollip antibody - ab37155 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Tollip antibody (ab37155) at 1 µg/mlLane 2 : Anti-Tollip antibody (ab37155) at 2 µg/mlLane 1 : Rat brain cell lysateLane 2 : Rat brain cell lysate

Anti-Tollip antibody - ab62578 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62578 at 2µg/ml staining Tollip in THP-1 cells by Immunocytochemistry.

Anti-Tollip antibody - ab115559 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115559, at 5µg/ml, staining Tollip in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Tollip antibody - ab56202 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Tollip antibody [1D1] - ab180398 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D1
All lanes : Anti-Tollip antibody [1D1] (ab180398) at 1/4000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Tollip cDNALysates/proteins at 5 µg per lane.

Anti-Tollip antibody [Kimmy-2] - ab16089 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone Kimmy-2
Immunohistochemical analysis of normal (upper) and tumour (lower) Human breast tissue, staining Tollip with ab16089. Antigen retrieval was performed via pressure cooking in a Tris-EDTA buffer (pH 9). Sections were blocked in BSA for 30 minutes before incubation with primary antibody (1/50) overnight at 4°C. Staining was detected using DAB.

Anti-TOLLIP Antibody (aa61-274, clone K1B17) - LS-C93808 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone K1B17
Cell lysates of Jurkat (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human Tollip (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Anti-TOLLIP Antibody (aa28-261, FITC) - LS-C304811 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TOLLIP Antibody (aa19-254, FITC) - LS-C304812 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TOLLIP Antibody - LS-C193106 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot.

Anti-TOLLIP Antibody (N-Terminus) - LS-C79975 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-TOLLIP Antibody (N-Terminus) - LS-C145755 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TOLLIP antibody LS-C145755 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-TOLLIP Antibody - LS-C26905 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of TOLLIP in rat brain cell lysate with TOLLIP antibody at (A) 0.5, (B) 1 and (C) 2 g/ml.

Anti-TOLLIP Antibody (aa19-254) - LS-C296691 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TOLLIP.

Anti-TOLLIP Antibody (aa28-261) - LS-C296692 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TOLLIP.

Anti-TOLLIP Antibody (clone 2A4) - LS-C338341 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A4
IHC of paraffin-embedded Human prostate tissue using anti-TOLLIP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-TOLLIP Antibody (clone 1D1) - LS-C338298 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TOLLIP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TOLLIP.

Anti-TOLLIP Antibody (clone 2E6) - LS-C338326 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E6
Anti-TOLLIP mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TOLLIP.

Anti-TOLLIP Antibody - LS-C331982 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach using TOLLIP antibody at dilution of 1:200 (x400 lens).

Anti-TOLLIP Antibody (Internal) IHC-plus™ - LS-B1426 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TOLLIP antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1426 concentration 5 ug/ml.
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