TOLLIP

Gene Symbol	TOLLIP
Entrez Gene	54472
Alt Symbol	IL-1RAcPIP
Species	Human
Gene Type	protein-coding
Description	toll interacting protein
Other Description	adapter protein|toll-interacting protein
Swissprots	Q9H9E6 Q9H0E2 Q9UJ69 B3KXC6
Accessions	EAX02433 EAX02434 EAX02435 Q9H0E2 AA861717 AB209541 BAD92778 AJ242972 CAB58118 AK022871 BAB14283 AK090850 BAG52240 AK096693 BAC04844 AK127123 BAG54438 AK315592 BAG37964 AL136835 CAB66769 AM393373 CAL38251 AY730683 AAX22229 BC004420 AAH04420 BC012057 AAH12057 BC018272 AAH18272 BX648136 CR533477 CAG38508 DB039994 DQ891802 ABM82728 DQ894986 ABM85912 XM_011520192 XP_011518494 NM_019009 NP_061882
Function	Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). {ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:25042851}.
Subcellular Location	Cytoplasm {ECO:0000305}.
Top Pathways	Toll-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Tollip peptide - ab40023 from Abcam Category Peptide Prices $176.00 Sizes 50 µg Species Human

Human Tollip full length protein - ab107146 from Abcam Category Protein Source E. coli Species Human

Human Tollip full length protein - ab172165 from Abcam Category Protein Source E. coli Species Human

TOLLIP Antibody Blocking Peptide - LS-E30213 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TOLLIP Antibody Blocking Peptide - LS-E30212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TOLLIP Antibody Blocking Peptide - LS-E11724 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TOLLIP Antibody Blocking Peptide - LS-E11089 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Tollip Recombinant Protein - H00054472-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Tollip Blocking Peptide - NBP1-77255PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Tollip Blocking Peptide - NBP1-76681PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human Tollip Protein - NBP1-72313 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

Tollip Peptide - P0528 from Novus Biologicals Category Peptide Species Human

Tollip Peptide - P0975 from Novus Biologicals Category Peptide Species Human

TOLLIP-Antibody-C-term-Blocking-Peptide - BP14351b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TOLLIP-Antibody-N-term-Blocking-Peptide - BP1521a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TOLLIP-Antibody-C-term-Blocking-Peptide - BP2163b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TOLLIP protein - orb169461 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human TOLLIP protein - orb49684 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

TOLLIP Blocking Peptide - 33R-5792 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TOLLIP protein (His tag) - 80R-1824 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

Human TOLLIP Protein - abx069354 from Abbexa Category Protein Source E.coli Species Human

TOLLIP Blocking Peptide - abx063887 from Abbexa Category Peptide Species Human, Monkey

TOLLIP (1-274, His-tag) - AR39007PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

TOLLIP (1-274, His-tag) - AR39007PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

TOLLIP - H00054472-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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