SIAH2

Gene Symbol	SIAH2
Entrez Gene	6478
Alt Symbol	hSiah2
Species	Human
Gene Type	protein-coding
Description	siah E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin-protein ligase SIAH2|seven in absentia homolog 2|siah-2
Swissprots	O43255 O43270
Accessions	EAW78821 O43255 AK055290 AK223565 BAD97285 AW377592 BC013082 AAH13082 BF514387 BM970396 U76248 AAC51908 Y15268 CAA75557 NM_005067 NP_005058
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradat
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity	Widely expressed at low level. {ECO:0000269|PubMed:9403064}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

seven in absentia homolog 2 (Drosophila) , ELISA Kit - MBS9342577 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.625 ng/ml - 20 ng/ml.

Human SIAH2 ELISA Kit - E097875 from Biobool Category ELISA Kit

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9345326 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9358760 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9349516 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9352854 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9358757 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9343594 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9367654 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9348734 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9364260 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9369110 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9348288 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9358231 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9358624 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9349133 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9360255 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9381851 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9345088 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9370119 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9361199 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit - MBS9349921 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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