SIAH2

Gene Symbol	SIAH2
Entrez Gene	6478
Alt Symbol	hSiah2
Species	Human
Gene Type	protein-coding
Description	siah E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin-protein ligase SIAH2|seven in absentia homolog 2|siah-2
Swissprots	O43255 O43270
Accessions	EAW78821 O43255 AK055290 AK223565 BAD97285 AW377592 BC013082 AAH13082 BF514387 BM970396 U76248 AAC51908 Y15268 CAA75557 NM_005067 NP_005058
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradat
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity	Widely expressed at low level. {ECO:0000269|PubMed:9403064}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIAH-2 (N-14) - sc-5507 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SIAH-2 (G-16) - sc-5508 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SIAH2 Antibody (N-Terminus) - LS-C112149 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa241-290) - LS-C120495 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (Glu266) - LS-C176983 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (N-Terminus, clone 24E6H3) - LS-C141889 from LifeSpan Bioscience Prices $335.00 Sizes 500 µl Host Mouse Clonality Monoclonal Clone 24E6H3

Anti-SIAH2 Antibody (aa216-244) - LS-C161085 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (N-Terminus) - LS-C144691 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (clone 1F5) - LS-C198195 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1F5

Anti-SIAH2 Antibody (aa216-244, AP) - LS-C217490 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa216-244, APC) - LS-C217492 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa216-244, Biotin) - LS-C217493 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa216-244, FITC) - LS-C217494 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa216-244, Azide-free, HRP) - LS-C217495 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa223-252) - LS-C325107 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa216-244, PE) - LS-C217496 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIAH2 Antibody (aa215-264) - LS-C109768 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

SIAH2 Antibody (24E6H3) - NB110-88113 from Novus Biologicals Prices $99.00, $299.00 Sizes 125 µl, 500 µl Host Mouse Clonality Monoclonal Clone 24E6H3

SIAH1/2 Antibody (8G7H12) - NB110-93596 from Novus Biologicals Prices $99.00, $279.00 Sizes 125 µl, 500 µl Host Mouse Clonality Monoclonal Clone 8G7H12

SIAH2 Antibody - NBP1-19648 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

SIAH2 Antibody - NBP1-68716 from Novus Biologicals Prices $229.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

SIAH2 Antibody (1F5) - H00006478-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1F5

SIAH1/2 Polyclonal Antibody - bs-3634R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-Siah2 antibody produced in mouse - S7945 from Sigma-Aldrich Prices $437.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone Siah2-369

Monoclonal Anti-SIAH2 antibody produced in mouse - WH0006478M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1F5

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