| Gene Symbol | SIAH2 |
|---|---|
| Entrez Gene | 6478 |
| Alt Symbol | hSiah2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | siah E3 ubiquitin protein ligase 2 |
| Other Description | E3 ubiquitin-protein ligase SIAH2|seven in absentia homolog 2|siah-2 |
| Swissprots | O43255 O43270 |
| Accessions | EAW78821 O43255 AK055290 AK223565 BAD97285 AW377592 BC013082 AAH13082 BF514387 BM970396 U76248 AAC51908 Y15268 CAA75557 NM_005067 NP_005058 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradat |
| Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. |
| Tissue Specificity | Widely expressed at low level. {ECO:0000269|PubMed:9403064}. |
SIAH-2 CRISPR/Cas9 KO Plasmid (h) - sc-401503 from Santa Cruz Biotechnology
|
||||||||
SIAH-2 HDR Plasmid (h) - sc-401503-HDR from Santa Cruz Biotechnology
|
||||||||
SIAH-2 Double Nickase Plasmid (h) - sc-401503-NIC from Santa Cruz Biotechnology
|
||||||||
SIAH-2 Double Nickase Plasmid (h2) - sc-401503-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SIAH-2 CRISPR Activation Plasmid (h) - sc-401503-ACT from Santa Cruz Biotechnology
|
||||||||
SIAH-2 CRISPR Activation Plasmid (h2) - sc-401503-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SIAH-2 Lentiviral Activation Particles (h) - sc-401503-LAC from Santa Cruz Biotechnology
|
||||||||
SIAH-2 Lentiviral Activation Particles (h2) - sc-401503-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SIAH-2 siRNA (h) - sc-37497 from Santa Cruz Biotechnology
|
||||||||
SIAH-2 shRNA Plasmid (h) - sc-37497-SH from Santa Cruz Biotechnology
|
||||||||
SIAH-2 shRNA (h) Lentiviral Particles - sc-37497-V from Santa Cruz Biotechnology
|
||||||||
SIAH2 RNAi - H00006478-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU027041 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19321 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19321 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR07807 from Sigma-Aldrich
|
||||||||
SIAH2 siRNA (Human) - CRH4379 from Cohesion Biosciences
|
||||||||
SIAH2 - MBS8234523 from MyBioSource
|
||||||||
shRNA set against Human Siah2 (NM_005067.5) - SHH407356 from Creative biogene
|
||||||||
shRNA set against Human SIAH2(NM_005067.5) - SHR225022 from Creative biogene
|
||||||||
Human SIAH2 siRNA - orb264881 from Biorbyt
|
||||||||
SIAH2 shRNA Plasmid (Human) - CHH4379 from Cohesion Biosciences
|
||||||||
SIAH2 miRNA 3'UTR clone - MiUTR1H-09389 from Creative biogene
|