SIAH2

Gene Symbol	SIAH2
Entrez Gene	6478
Alt Symbol	hSiah2
Species	Human
Gene Type	protein-coding
Description	siah E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin-protein ligase SIAH2|seven in absentia homolog 2|siah-2
Swissprots	O43255 O43270
Accessions	EAW78821 O43255 AK055290 AK223565 BAD97285 AW377592 BC013082 AAH13082 BF514387 BM970396 U76248 AAC51908 Y15268 CAA75557 NM_005067 NP_005058
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradat
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity	Widely expressed at low level. {ECO:0000269|PubMed:9403064}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Siah2 full length protein - ab132352 from Abcam Category Protein Source Wheat germ Species Human

Human Siah2 full length protein - ab159504 from Abcam Category Protein Source Wheat germ Species Human

Human Siah2 peptide - ab28592 from Abcam Category Peptide

Human Siah2 protein fragment - ab159506 from Abcam Category Protein Source Wheat germ Species Human

SIAH2 Antibody Blocking Peptide - LS-E8024 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIAH2 Antibody Blocking Peptide - LS-E11735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIAH2 Antibody Blocking Peptide - LS-E21248 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SIAH2 Protein - H00006478-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SIAH2 Protein - H00006478-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SIAH2-Antibody-Center-Blocking-peptide - BP5878c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIAH2 - H00006478-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SIAH2 - H00006478-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SIAH2 - H00006478-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SIAH2 - H00006478-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SIAH2 fusion protein - ag3342 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Siah-2 (E266) Peptide - BS2425P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human E3 ubiquitin-protein ligase SIAH2(SIAH2) - CSB-YP021288HU CSB-EP021288HU CSB-BP021288HU CSB-MP021288HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SIAH2 Blocking Peptide - CBP4236 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

SIAH2 Blocking Peptide - abx161447 from Abbexa Category Peptide Species Human, Mouse, Rat, Zebrafish

SIAH2 - TP303802 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SIAH2 Peptide, Human - M34GP14232H from Creative Peptides Category Peptide Source Synthetic. Species Human

SIAH2 Recombinant Protein Antigen - NBP2-56198PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E3 ubiquitin-protein ligase SIAH2 (SIAH2), Recombinant Protein - MBS1264671 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,705.00, $1,705.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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