SIAH2

Gene Symbol	SIAH2
Entrez Gene	6478
Alt Symbol	hSiah2
Species	Human
Gene Type	protein-coding
Description	siah E3 ubiquitin protein ligase 2
Other Description	E3 ubiquitin-protein ligase SIAH2|seven in absentia homolog 2|siah-2
Swissprots	O43255 O43270
Accessions	EAW78821 O43255 AK055290 AK223565 BAD97285 AW377592 BC013082 AAH13082 BF514387 BM970396 U76248 AAC51908 Y15268 CAA75557 NM_005067 NP_005058
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradat
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity	Widely expressed at low level. {ECO:0000269|PubMed:9403064}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIAH2 overexpression lysate - LY417551 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIAH2 293 Cell Lysate - 408213 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

SIAH2 Overexpression Lysate (Native) - NBL1-15955 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIAH2 Over-expression Lysate Product - GWB-CC576F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human SIAH2 Knockdown Stable Cell Line - CSC-DC014232 from Creative biogene Category Cell Line Species Human

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