| Gene Symbol |
ITGA8
|
| Entrez Gene |
8516
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, alpha 8
|
| Other Description |
integrin alpha-8
|
| Swissprots |
Q5VX94 B0YJ31 P53708
|
| Accessions |
AAQ56848 ACA06009 EAW86235 P53708 AK297740 BAG60090 AK308240 BC148352 AAI48353 BU735798 DB237365 DC425586 L36531 AAA93514 XM_011519752 XP_011518054 NM_001291494 NP_001278423 NM_003638 NP_003629
|
| Function |
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269|PubMed:24439109}. Cell membrane {ECO:0000269|PubMed:24439109}.
|
| Tissue Specificity |
Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level). {ECO:0000269|PubMed:10504498, ECO:0000269|PubMed:7768999}.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Cell adhesion molecules (CAMs), Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|