ITGA8

Gene Symbol ITGA8
Entrez Gene 8516
Alt Symbol -
Species Human
Gene Type protein-coding
Description integrin, alpha 8
Other Description integrin alpha-8
Swissprots Q5VX94 B0YJ31 P53708
Accessions AAQ56848 ACA06009 EAW86235 P53708 AK297740 BAG60090 AK308240 BC148352 AAI48353 BU735798 DB237365 DC425586 L36531 AAA93514 XM_011519752 XP_011518054 NM_001291494 NP_001278423 NM_003638 NP_003629
Function Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.
Subcellular Location Membrane {ECO:0000269|PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269|PubMed:24439109}. Cell membrane {ECO:0000269|PubMed:24439109}.
Tissue Specificity Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level). {ECO:0000269|PubMed:10504498, ECO:0000269|PubMed:7768999}.
Top Pathways Focal adhesion, ECM-receptor interaction, Cell adhesion molecules (CAMs), Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Integrin α8 CRISPR/Cas9 KO Plasmid (h) - sc-402020 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 HDR Plasmid (h) - sc-402020-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 Double Nickase Plasmid (h) - sc-402020-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 Double Nickase Plasmid (h2) - sc-402020-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 CRISPR Activation Plasmid (h) - sc-402020-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 CRISPR Activation Plasmid (h2) - sc-402020-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 Lentiviral Activation Particles (h) - sc-402020-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 Lentiviral Activation Particles (h2) - sc-402020-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Integrin α8 siRNA (h) - sc-35688 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin α8 shRNA Plasmid (h) - sc-35688-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin α8 shRNA (h) Lentiviral Particles - sc-35688-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Integrin alpha 8 RNAi - H00008516-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU043621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10810 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10810 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ITGA8 siRNA (Human) - CRH5589 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ITGA8 - MBS8217833 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ITGA8 (NM_003638.1) - SHH321245 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ITGA8(NM_003638.1) - SHL181668 from Creative biogene

Category siRNA
Species Reactivities Human

ITGA8 shRNA Plasmid (Human) - CHH5589 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ITGA8 miRNA 3'UTR clone - MiUTR1H-05025 from Creative biogene

Species Reactivities Human
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