| Gene Symbol |
CNOT7
|
| Entrez Gene |
29883
|
| Alt Symbol |
CAF1, Caf1a, hCAF-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 7
|
| Other Description |
BTG1 binding factor 1|BTG1-binding factor 1|CAF-1|CCR4-NOT transcription complex subunit 7|CCR4-associated factor 1|carbon catabolite repressor protein (CCR4)-associative factor 1
|
| Swissprots |
Q9UIV1 B3KMP1 B3KN35 Q7Z530 D3DSP6 A8MZM5 G3V108
|
| Accessions |
CAE90224 EAW63820 EAW63821 EAW63822 EAW63823 Q9UIV1 AA134869 AA165288 AF086915 AAP97145 AK001209 BAG50869 AK021808 BAG51053 AK023466 BAG51197 AK023561 AK090522 AK225893 AL833642 AW448990 BC007315 AAH07315 BC060852 AAH60852 BC070187 AAH70187 BM468592 BT006685 AAP35331 DA752620 L46722 AAF01500 XM_005273481 XP_005273538 XM_011544511 XP_011542813 NM_013354 NP_037486 NM_054026 NP_473367
|
| Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.
|
| Subcellular Location |
Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
|
| Top Pathways |
RNA degradation
|
![Western Blot: CNOT7 Overexpression Lysate (Adult Normal) [NBL1-09320] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNOT7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9077_CNOT7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09320-img0002.jpg)