CNOT7

Gene Symbol CNOT7
Entrez Gene 29883
Alt Symbol CAF1, Caf1a, hCAF-1
Species Human
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 7
Other Description BTG1 binding factor 1|BTG1-binding factor 1|CAF-1|CCR4-NOT transcription complex subunit 7|CCR4-associated factor 1|carbon catabolite repressor protein (CCR4)-associative factor 1
Swissprots Q9UIV1 B3KMP1 B3KN35 Q7Z530 D3DSP6 A8MZM5 G3V108
Accessions CAE90224 EAW63820 EAW63821 EAW63822 EAW63823 Q9UIV1 AA134869 AA165288 AF086915 AAP97145 AK001209 BAG50869 AK021808 BAG51053 AK023466 BAG51197 AK023561 AK090522 AK225893 AL833642 AW448990 BC007315 AAH07315 BC060852 AAH60852 BC070187 AAH70187 BM468592 BT006685 AAP35331 DA752620 L46722 AAF01500 XM_005273481 XP_005273538 XM_011544511 XP_011542813 NM_013354 NP_037486 NM_054026 NP_473367
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.
Subcellular Location Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
Top Pathways RNA degradation

Human-CNOT7-cDNA-Clone - DC08214 from Abgent, a WuXi AppTec company

Prices $332.10
Sizes 10 µg
Species Human
Accession BC007315

CNOT7 - MBS1277289 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC060852

CNOT7 - MBS1274476 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC007315

Human CNOT7 cDNA clone(NM_054026.2) - CDFG007205 from Creative Biomart

Species Human
Accession NM_054026.2

Human CNOT7 cDNA clone(NM_013354.5) - CDFH003959 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_013354.5) - CDCR296477 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_013354.5) - CDCR296478 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_013354.5) - CDCR296479 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_054026.2) - CDCR314480 from Creative Biomart

Species Human
Accession NM_054026.2

Human CNOT7 ORF Clone(NM_054026.2) - CDCR314641 from Creative Biomart

Species Human
Accession NM_054026.2

Human CNOT7 ORF Clone(NM_013354.5) - CDCL159271 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_013354.5) - CDCL159272 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_013354.5) - CDCL159273 from Creative Biomart

Species Human
Accession NM_013354.5

Human CNOT7 Gene cDNA Clone (full-length ORF Clone) - HG16519-U from Sino Biological

Species Human
Accession NM_013354.5

Human CNOT7 natural ORF mammalian expression plasmid, C-Myc tag - HG16519-CM from Sino Biological

Species Human
Accession NM_013354.5

Human CNOT7 natural ORF mammalian expression plasmid, C-HA tag - HG16519-CY from Sino Biological

Species Human
Accession NM_013354.5

Human CNOT7 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG16519-ACG from Sino Biological

Species Human
Accession NM_013354.5

Human CNOT7 natural ORF mammalian expression plasmid, N-Myc tag - HG16519-NM from Sino Biological

Species Human
Accession NM_013354.5

Human CNOT7 ORF Clone(NM_013354.5) - CDCR296477 from Creative biogene

Species Human
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