CNOT7

Gene Symbol CNOT7
Entrez Gene 29883
Alt Symbol CAF1, Caf1a, hCAF-1
Species Human
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 7
Other Description BTG1 binding factor 1|BTG1-binding factor 1|CAF-1|CCR4-NOT transcription complex subunit 7|CCR4-associated factor 1|carbon catabolite repressor protein (CCR4)-associative factor 1
Swissprots Q9UIV1 B3KMP1 B3KN35 Q7Z530 D3DSP6 A8MZM5 G3V108
Accessions CAE90224 EAW63820 EAW63821 EAW63822 EAW63823 Q9UIV1 AA134869 AA165288 AF086915 AAP97145 AK001209 BAG50869 AK021808 BAG51053 AK023466 BAG51197 AK023561 AK090522 AK225893 AL833642 AW448990 BC007315 AAH07315 BC060852 AAH60852 BC070187 AAH70187 BM468592 BT006685 AAP35331 DA752620 L46722 AAF01500 XM_005273481 XP_005273538 XM_011544511 XP_011542813 NM_013354 NP_037486 NM_054026 NP_473367
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.
Subcellular Location Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
Top Pathways RNA degradation

CNOT7 CRISPR/Cas9 KO Plasmid (h) - sc-416448 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 HDR Plasmid (h) - sc-416448-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 Double Nickase Plasmid (h) - sc-416448-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 Double Nickase Plasmid (h2) - sc-416448-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 CRISPR Activation Plasmid (h) - sc-416448-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 CRISPR Activation Plasmid (h2) - sc-416448-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 Lentiviral Activation Particles (h) - sc-416448-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 Lentiviral Activation Particles (h2) - sc-416448-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CNOT7 siRNA (h) - sc-72946 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CNOT7 shRNA Plasmid (h) - sc-72946-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CNOT7 shRNA (h) Lentiviral Particles - sc-72946-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CNOT7 RNAi - H00029883-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

CNOT7 RNAi - H00029883-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU129081 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6325 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CNOT7 siRNA (Human) - CRH9246 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CNOT7 - MBS8226415 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CNOT7 (NM_013354.5) - SHH266485 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CNOT7(NM_054026.2) - SHG136537 from Creative biogene

Category siRNA
Species Reactivities Human

Human CNOT7 siRNA - orb269748 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CNOT7 shRNA Plasmid (Human) - CHH9246 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CNOT7 miRNA 3'UTR clone - MiUTR1H-02281 from Creative biogene

Species Reactivities Human

CNOT7 miRNA 3'UTR clone - MiUTR1H-02282 from Creative biogene

Species Reactivities Human
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