CNOT7

Gene Symbol	CNOT7
Entrez Gene	29883
Alt Symbol	CAF1, Caf1a, hCAF-1
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 7
Other Description	BTG1 binding factor 1\|BTG1-binding factor 1\|CAF-1\|CCR4-NOT transcription complex subunit 7\|CCR4-associated factor 1\|carbon catabolite repressor protein (CCR4)-associative factor 1
Swissprots	Q9UIV1 B3KMP1 B3KN35 Q7Z530 D3DSP6 A8MZM5 G3V108
Accessions	CAE90224 EAW63820 EAW63821 EAW63822 EAW63823 Q9UIV1 AA134869 AA165288 AF086915 AAP97145 AK001209 BAG50869 AK021808 BAG51053 AK023466 BAG51197 AK023561 AK090522 AK225893 AL833642 AW448990 BC007315 AAH07315 BC060852 AAH60852 BC070187 AAH70187 BM468592 BT006685 AAP35331 DA752620 L46722 AAF01500 XM_005273481 XP_005273538 XM_011544511 XP_011542813 NM_013354 NP_037486 NM_054026 NP_473367
Function	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269\|PubMed:19605561, ECO:0000269\|PubMed:20065043, ECO:0000269\|PubMed:20634287, ECO:0000269\|PubMed:23236473}.
Subcellular Location	Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
Top Pathways	RNA degradation

CNOT7 (E-16) - sc-82835 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CNOT7 (E-16): sc-82835. Western blot analysis of CNOT7 expression in KNRK whole cell lysate (A) and mouse testis tissue extract (B).

CNOT7 (18W) - sc-101009 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

CNOT7 (18W): sc-101009. Western blot analysis of CNOT7 expression in HeLa whole cell lysate.

Anti-CNOT7 antibody - ab57095 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-CNOT7 antibody - ab103714 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 antibody - ab105525 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 antibody (ab105525) at 0.25 µg/ml + HepG2 cell lysate at 10 µg

Anti-CNOT7 antibody - ab136118 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 antibody (ab136118) at 1/500 dilution + HuVEC cell lysate at 30 µg

Anti-CNOT7 Antibody (aa19-68) - LS-C291817 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-90) - LS-C30380 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-68) - LS-C319978 from LifeSpan Bioscience

Prices	$435.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody - LS-C307008 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-CNOT7 Antibody (aa10-59) - LS-C119313 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from HeLa/HUVEC cells, using CNOT7 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CNOT7 Antibody (aa179-228) - LS-C109690 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

CNOT7 antibody LS-C109690 Western blot of Placenta lysate.

Anti-CNOT7 Antibody (aa41-68) - LS-C168269 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

CAF-1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CNOT7 Antibody (aa41-68, APC) - LS-C233350 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-68, AP) - LS-C233351 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-68, Biotin) - LS-C233353 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-68, PE) - LS-C233357 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-68, FITC) - LS-C233354 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CNOT7 Antibody (aa41-68, Azide-free, HRP) - LS-C249567 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

CNOT7 Antibody (2F6) - H00029883-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2F6

Western Blot: CNOT7 Antibody (2F6) [H00029883-M01] - CNOT7 monoclonal antibody (M01), clone 2F6. Analysis of CNOT7 expression in Raw 264.7.

CNOT7 Antibody - NBP2-29987 from Novus Biologicals

Prices	$299.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CNOT7 Antibody [NBP2-29987] - Western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CAF-1 antibody detected the CAF-1 protein (arrow).

CNOT7 Antibody - NBP2-15929 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CNOT7 Antibody [NBP2-15929] - Sample (30 ug of whole cell lysate) A: U87-MG 12% SDS PAGE gel, diluted at 1:1000.

CNOT7 Antibody - NBP1-55749 from Novus Biologicals

Prices	$229.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: CNOT7 Antibody [NBP1-55749] - Analysis of extracts from HeLa/HuvEc cells, using CNOT7 Antibody. The lane on the right is treated with the synthesized peptide.

CNOT7 Antibody (2F6) - H00029883-M01A from Novus Biologicals

Prices	$349.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	2F6

CNOT7 Antibody - H00029883-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

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